Document Detail

The influx of isoleucine into the cerebral hemispheres and cerebellum: carrier-mediated transport and diffusion.
MedLine Citation:
PMID:  585479     Owner:  NLM     Status:  MEDLINE    
The influx of L-isoleucine from the blood into the cerebral hemispheres, and into the cerebellum, of the living rat was studied. When various raised levels of L-isoleucine were maintained in the circulation, influx did not increase in proportion to the raised blood levels, which showed that a carrier-mediated transport was being saturated. It was found that the values for influx could not be explained precisely by Michaelis-Menten kinetics. The divergence of the observed values for influx, from those which were obtained by the application of Michaelis-Menten kinetics, could be explained if part of the influx was due to a small, non-saturable component. This minor component of influx may be due to diffusion or to a second carrier-mediated transport system that is not readily saturated.
P M Daniel; O E Pratt; P A Wilson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Quarterly journal of experimental physiology and cognate medical sciences     Volume:  62     ISSN:  0033-5541     ISO Abbreviation:  Q J Exp Physiol Cogn Med Sci     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-06-11     Completed Date:  1977-06-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404466     Medline TA:  Q J Exp Physiol Cogn Med Sci     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  163-73     Citation Subset:  IM    
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MeSH Terms
Biological Transport, Active
Blood-Brain Barrier
Brain / metabolism*
Cerebellum / metabolism
Isoleucine / blood,  metabolism*
Reg. No./Substance:

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