| The influences of blood glucose and duration of fasting on myocardial glucose uptake of [18F]fluoro-2-deoxy-D-glucose. | |
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MedLine Citation:
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PMID: 12352594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the study of chest using positron emission tomography (PET) with [18F]fluoro-2-deoxy-d-glucose (FDG), a significant myocardial FDG uptake can prevent detection of the lesion that is located either behind or closely attached to the heart border. Two well-known and possible factors of myocardial FDG uptake are blood glucose level and fasting duration before FDG PET scanning. This study investigates whether the two factors are related to myocardial FDG uptake. Our study also explores the possibility of eliminating myocardial FDG uptake by controlling patients' blood glucose level and/or fasting duration. Whole-body FDG PET scans performed on 270 consecutive patients performed were reviewed. The study subjects were classified into four grades of myocardial FDG uptake according to the visual interpretation of the FDG PET image hard-copy films. For all study subjects, the blood sugar level and fasting duration before FDG injection were recorded. Then, the blood sugar levels and fasting duration were compared to the visual grade of myocardial FDG uptake for each study subject. About half of the study subjects showed graded 0 myocardial FDG uptake when the blood glucose levels were < or = 120 mg x dl(-1) or when the fasting duration was between 5 and 12 h. One hundred and thirty-one of the 142 (92%) patients with graded 0 uptake were asked to fast for > or = 4 h and had blood glucose levels < or = 120 mg x dl(-1). Based on our findings, we conclude that controlling the patients' blood glucose levels to < or = 120 mg x dl(-1) and at least 5 h fasting should be recommended to decrease myocardial FDG uptake. |
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Authors:
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H J Ding; Y C Shiau; J J Wang; S T Ho; A Kao |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 23 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-27 Completed Date: 2003-05-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
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Languages: eng Pagination: 961-5 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Lippincott Williams & Wilkins |
Affiliation:
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Department of Medical Research, School of Technology for Medical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Glucose / metabolism* Fasting / physiology* Female Fluorodeoxyglucose F18 / pharmacokinetics* Glucose / metabolism* Heart / radionuclide imaging Humans Male Middle Aged Myocardium / metabolism* Radiopharmaceuticals / pharmacokinetics* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Radiopharmaceuticals; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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