Document Detail


The influence of zinc on the ontogeny of hepatic metallothionein in the fetal rat.
MedLine Citation:
PMID:  7323068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ontogeny of hepatic metallothioneins (Mt) in fetal tissue as related to dietary and hepatic Zn was investigated. Sixty 6-month-old female rats were divided into two groups and given either double-distilled water or water containing 700 mug of Zn per milliliter. Dams from each group were killed on 16, 19, or 21 days of gestation, and maternal and fetal livers were removed. Mt content of the tissue was estimated by Piotrowski's Hg-saturation method. Results established the presence of an endogenous hepatic Mt in the fetal rat as early as 16 days of gestation. We further demonstrated a marked progressive increase in fetal Mt from Day 16 through gestation accompanied by a decrease in maternal hepatic Mt. It is suggested that Zn increased fetal Mt by inducing fetal synthesis, redistributing fetal Mt, or increasing Mt transport to the fetus, because both fetal and maternal hepatic Mt were increased. Fetal hepatic Mt concentration was several times greater than maternal Mt at corresponding stages of gestation. Mt may serve to either ensure adequate storage of Zn or Cu for fetal development or protect the fetus against metal toxicity, but the significance of these high endogenous levels of fetal Mt are not clear at this time.
Authors:
V L Charles-Shannon; L B Sasser; D K Burbank; B J Kelman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  168     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1982-03-26     Completed Date:  1982-03-26     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  56-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fetus / metabolism*
Liver / metabolism*
Mercury / metabolism
Metalloproteins / metabolism*
Metallothionein / metabolism*
Placenta / metabolism
Pregnancy
Rats
Rats, Inbred Strains
Zinc / metabolism,  pharmacology*
Chemical
Reg. No./Substance:
0/Metalloproteins; 7439-97-6/Mercury; 7440-66-6/Zinc; 9038-94-2/Metallothionein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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