Document Detail

The influence of vitamin E on capsule formation and contracture around silicone implants.
MedLine Citation:
PMID:  7006489     Owner:  NLM     Status:  MEDLINE    
An attempt was made to determine if the tissue response to surgical trauma and foreign body stimulus (silicone implants) could be altered using vitamin E in rats. The animals were divided into four groups: Group A served as controls, Group B were treated by intramuscular vitamin E, Group C were treated topically with vitamin E around the prosthesis, and Group D were treated topically with croton oil around the prosthesis. The animals in each group were killed at 2 week, 1 month, and 3 months intervals. The intraprosthetic pressure in each prosthesis was recorded using a strain gauge transducer. The capsules were then removed and examined histologically using a light microscope and the thickness of pseudocapsules was measured with an ocular micrometer. In Group B significantly thinner pseudocapsules were observed at 2 weeks, but there was no comparable difference either in thickness or degree of contracture (as measured by intraprosthetic pressures) between Groups A and B at 2 months and 3 months. In Group C, the pseudocapsules were significantly thicker at all tested periods and showed noticeable contracture at 3 months. In group D the pseudocapsules were thickest and cellular infiltrate more marked than in the other groups.
C R Peters; T E Shaw; D R Raju
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  5     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-52     Citation Subset:  IM    
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MeSH Terms
Administration, Topical
Anti-Inflammatory Agents / pharmacology
Contracture / epidemiology
Croton Oil / administration & dosage
Foreign-Body Reaction / pathology,  prevention & control
Injections, Intramuscular
Muscles / pathology
Prostheses and Implants*
Silicone Elastomers / toxicity*
Skin / pathology
Vitamin E / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Silicone Elastomers; 1406-18-4/Vitamin E; 8001-28-3/Croton Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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