Document Detail


The influence of varying inspired fractions of O(2) and CO(2) on the development of involuntary breathing movements during maximal apnoea.
MedLine Citation:
PMID:  22465545     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The growing urge to breathe that occurs during breath-holding results in development of involuntary breathing movements (IBMs). The present study determined whether IBMs are initiated at critical levels of hypercapnia and/or hypoxia during maximal apnoea. Arterial blood gasses at the onset of IBM were monitored during maximal voluntary breath-holds. Eleven healthy men performed breath holds after breathing air, hyperoxic-normocapnia, hypoxic-normocapnia, and normoxic-hypercapnia. Pre-breathing of the gas mixtures facilitated the IBM onset, reducing the time-to-onset for ∼46% (hyperoxic condition) and for ∼80% (hypoxic condition) compared to the normoxic air breathing time. A strong correlation (R=0.83, P=0.002) between arterial partial pressure of CO(2) ( [Formula: see text] ) at IBM onset after pre-breathing hyperoxic and hypercapnic gas mixtures was observed, suggesting the existence of a possible IBM [Formula: see text] threshold level of ∼6.5±0.5kPa. No clear "threshold" was observed for partial pressure of arterial O(2) ( [Formula: see text] ). However, we observed that IBM onset was influenced, in part, by an interaction between [Formula: see text] and [Formula: see text] levels during maximal apnoea. This study demonstrated the complex interaction between arterial blood-gases and the physiological response to maximal breath holding.
Authors:
Toni Breskovic; Mihajlo Lojpur; Petra Zubin Maslov; Troy J Cross; Jasenka Kraljevic; Marko Ljubkovic; Jasna Marinovic; Vladimir Ivancev; Bruce D Johnson; Zeljko Dujic
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-20
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Integrative Physiology, University of Split School of Medicine, Split, Croatia.
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