| The influence of ubiquinone (Co Q10) on the metabolic response to work. | |
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MedLine Citation:
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PMID: 2671499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ubiquinone (Co Q10) is a natural substance suitable for therapeutic use in cardiology and in the treatment of some muscular diseases. It might therefore be used during strenuous exercise (as in athletic competitions), especially in the presence of metabolic modifications which may justify its use. For this purpose, we have evaluated the effect of prolonged treatment with Co Q10 (100 mg/day per os for one month) on the biological changes induced by prolonged work on an ergometer bicycle (equal to about 50% of the single VO2max per 60 m'), immediately followed by exhaustive work (25 watts increase every 2 m'). From the venous blood of 12 healthy untrained subjects (students, volunteers, mean age 25.7 and body mass index 23.3) we examined some biological parameters [free fatty acids (FFA), free glycerol, lactate, glucose, insulin, CK] before, at the end of aerobic work, at the end of exhaustive work, and after 30 and 60 m' of the recovery phase. The same indexes, measured after identical times and work, were evaluated after one month of treatment with Co Q10. The only relevant modifications observed were those concerning FFA: at the end of aerobic work and after the administration of the drug, lower levels were reached (before, 1011 +/- 329 microEq/l; after 790 +/- 392; p less than 0.05); the same trend was observed at the end of the exhaustive work (1031 +/- 320 microEq/l vs 826 +/- 387; p less than 0.05). At the subsequent times, as well as for the other biological parameters examined, we did not observe any variation before or after the period of treatment.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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U Zuliani; A Bonetti; M Campana; G Cerioli; F Solito; A Novarini |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of sports medicine and physical fitness Volume: 29 ISSN: 0022-4707 ISO Abbreviation: J Sports Med Phys Fitness Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-09-28 Completed Date: 1989-09-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376337 Medline TA: J Sports Med Phys Fitness Country: ITALY |
Other Details:
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Languages: eng Pagination: 57-62 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Evaluation Studies as Topic Exercise Humans Male Muscles / drug effects*, metabolism Sports Ubiquinone / pharmacology* |
| Chemical | |
Reg. No./Substance:
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1339-63-5/Ubiquinone; 7704-04-3/Ubiquinone Q2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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