Document Detail

The influence of triclosan, zinc or propylene glycol on oral mucosa exposed to sodium lauryl sulphate.
MedLine Citation:
PMID:  9395119     Owner:  NLM     Status:  MEDLINE    
Previous studies on triclosan treatment of skin exposed to sodium lauryl sulphate (SLS) indicated a protective rôle of zinc and an irritant effect of propylene glycol (PG). The aim was hence to examine whether zinc or PG also may affect SLS-induced oral mucosal reactions, and also to test the influence of zinc in combination with triclosan. 15 healthy dental students participated in this double-blind crossover study performed in 2 experimental series. They were rinsing 2x daily with solutions containing (A) 1.5% SLS, (B) 1.5% SLS/0.5% zinc citrate and (C) 1.5% SLS/PG (1:8) in experiment 1, and (D) 1.5% SLS/0.15% triclosan/0.3% zinc citrate and (E) 1.5% SLS/0.15% triclosan in experiment 2. Clinical evaluation by 2 examiners of degree of erythema and oral mucosal desquamations was then performed. The critical micellar concentration was also determined. SLS and SLS/PG, which were not different in effect, evoked significantly more erythematous reactions than SLS/Tri/Zn. This solution was numerically but not statistically better than SLS/Tri, and the latter also did lead to significantly less erythema than SLS/PG. In conclusion, the present study revealed no irritation of the oral mucosa due to PG, whereas a protective effect of zinc as well as the anti-inflammatory effect of triclosan were confirmed.
A B Skaare; G Rölla; P Barkvoll
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of oral sciences     Volume:  105     ISSN:  0909-8836     ISO Abbreviation:  Eur. J. Oral Sci.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-13     Completed Date:  1998-01-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9504563     Medline TA:  Eur J Oral Sci     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  527-33     Citation Subset:  D; IM    
Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Norway.
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MeSH Terms
Anti-Infective Agents, Local / pharmacology*
Anti-Inflammatory Agents / pharmacology*
Cross-Over Studies
Dermatologic Agents / pharmacology
Double-Blind Method
Erythema / chemically induced
Irritants / pharmacology*
Mouth Diseases / chemically induced
Mouth Mucosa / drug effects*
Propylene Glycol / pharmacology*
Skin / drug effects
Sodium Dodecyl Sulfate / pharmacology*
Surface-Active Agents / pharmacology*
Triclosan / pharmacology*
Zinc / pharmacology*
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Anti-Inflammatory Agents; 0/Dermatologic Agents; 0/Irritants; 0/Surface-Active Agents; 151-21-3/Sodium Dodecyl Sulfate; 3380-34-5/Triclosan; 57-55-6/Propylene Glycol; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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