| The influence of triclosan, zinc or propylene glycol on oral mucosa exposed to sodium lauryl sulphate. | |
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MedLine Citation:
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PMID: 9395119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies on triclosan treatment of skin exposed to sodium lauryl sulphate (SLS) indicated a protective rôle of zinc and an irritant effect of propylene glycol (PG). The aim was hence to examine whether zinc or PG also may affect SLS-induced oral mucosal reactions, and also to test the influence of zinc in combination with triclosan. 15 healthy dental students participated in this double-blind crossover study performed in 2 experimental series. They were rinsing 2x daily with solutions containing (A) 1.5% SLS, (B) 1.5% SLS/0.5% zinc citrate and (C) 1.5% SLS/PG (1:8) in experiment 1, and (D) 1.5% SLS/0.15% triclosan/0.3% zinc citrate and (E) 1.5% SLS/0.15% triclosan in experiment 2. Clinical evaluation by 2 examiners of degree of erythema and oral mucosal desquamations was then performed. The critical micellar concentration was also determined. SLS and SLS/PG, which were not different in effect, evoked significantly more erythematous reactions than SLS/Tri/Zn. This solution was numerically but not statistically better than SLS/Tri, and the latter also did lead to significantly less erythema than SLS/PG. In conclusion, the present study revealed no irritation of the oral mucosa due to PG, whereas a protective effect of zinc as well as the anti-inflammatory effect of triclosan were confirmed. |
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Authors:
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A B Skaare; G Rölla; P Barkvoll |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: European journal of oral sciences Volume: 105 ISSN: 0909-8836 ISO Abbreviation: Eur. J. Oral Sci. Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1998-01-13 Completed Date: 1998-01-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9504563 Medline TA: Eur J Oral Sci Country: DENMARK |
Other Details:
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Languages: eng Pagination: 527-33 Citation Subset: D; IM |
Affiliation:
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Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Norway. askaare@odont.uio.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Infective Agents, Local / pharmacology* Anti-Inflammatory Agents / pharmacology* Cross-Over Studies Dermatologic Agents / pharmacology Double-Blind Method Erythema / chemically induced Female Humans Irritants / pharmacology* Male Mouth Diseases / chemically induced Mouth Mucosa / drug effects* Propylene Glycol / pharmacology* Skin / drug effects Sodium Dodecyl Sulfate / pharmacology* Surface-Active Agents / pharmacology* Triclosan / pharmacology* Zinc / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Anti-Inflammatory Agents; 0/Dermatologic Agents; 0/Irritants; 0/Surface-Active Agents; 151-21-3/Sodium Dodecyl Sulfate; 3380-34-5/Triclosan; 57-55-6/Propylene Glycol; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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