Document Detail

The influence of transdermal nicotine on tobacco/nicotine abstinence and the effects of a concurrently administered cigarette in women and men.
MedLine Citation:
PMID:  18489014     Owner:  NLM     Status:  MEDLINE    
Transdermal nicotine (TN) is an efficacious smoking cessation pharmacotherapy thought to work, in part, by attenuating the effects of tobacco/nicotine abstinence and the effects of concurrently smoked cigarettes. Clinical trials suggest that TN may be less efficacious for women. This study explored the possibility of TN-related gender differences in > or = 8 hour abstinent smokers (54 women, 70 men) who completed four within-subject, double-blind, placebo-controlled sessions corresponding to 0, 7, 14, and 21 mg TN. In each approximately 6.5-hr long session participants smoked an own-brand cigarette 4 hours after TN administration and physiological and subjective outcomes were examined throughout each session. Results revealed that TN suppressed some signs and symptoms of tobacco abstinence and attenuated some effects of smoking, and these effects were not dependent on gender. Women were more sensitive to the direct effects of nicotine (e.g., ratings of Nauseous) and, independent of TN dose, self-administered less nicotine when smoking and rated smoking as less rewarding. Thus, although this study does not shed light on clinical observations that TN is less effective for women, results suggest that TN might need to be combined with other interventions to supplement its effects on tobacco/nicotine abstinence and concurrent smoking.
Bethea A Kleykamp; Janine M Jennings; Cynthia Sams; Michael F Weaver; Thomas Eissenberg
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Experimental and clinical psychopharmacology     Volume:  16     ISSN:  1064-1297     ISO Abbreviation:  Exp Clin Psychopharmacol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-20     Completed Date:  2008-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9419066     Medline TA:  Exp Clin Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-112     Citation Subset:  IM    
Department of Psychology, Virginia Commonwealth University, Richmond, VA 23298-0205, USA.
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MeSH Terms
Administration, Cutaneous
Analysis of Variance
Case-Control Studies
Dose-Response Relationship, Drug
Double-Blind Method
Menstrual Cycle
Nicotine / administration & dosage*,  adverse effects,  blood
Nicotinic Agonists / administration & dosage*,  adverse effects,  blood
Sex Characteristics*
Smoking / psychology*
Tobacco Use Cessation
Tobacco Use Disorder / drug therapy*,  physiopathology,  psychology
Grant Support
Reg. No./Substance:
0/Nicotinic Agonists; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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