Document Detail

The influence of tomograph sensitivity on kinetic parameter estimation in positron emission tomography imaging studies of the rat brain.
MedLine Citation:
PMID:  11056379     Owner:  NLM     Status:  MEDLINE    
We investigated the influence of tomograph sensitivity on reliability of parameter estimation in positron emission tomography studies of the rat brain. The kinetics of two tracers in rat striatum and cerebellum were simulated. A typical injected dose of 10 MBq and a reduced dose of 1 MBq were assumed. Kinetic parameters were estimated using a region of interest (ROI) analysis and two pixel-by-pixel analyses. Striatal binding potential was estimated as a function of effective tomograph sensitivity (S(eff)) using a simplified reference tissue model. A S(eff) value of > or =1% was required to ensure reliable parameter estimation for ROI analysis and a S(eff) of 3-6% was required for pixel-by-pixel analysis. We conclude that effective tomograph sensitivity of 3% may be an appropriate design goal for rat brain imaging.
S R Meikle; S Eberl; R R Fulton; M Kassiou; M J Fulham
Related Documents :
1859839 - Structural characterization and tissue-specific expression of the mrnas encoding isoenz...
11738649 - Localization of connexin26 and connexin32 in putative co(2)-chemosensitive brainstem re...
12668219 - Findings in normal rats following administration of gliadorphin-7 (gd-7).
8597299 - Rat hippocampal mossy fibers contain cholecystokinin-like immunoreactivity.
631269 - Large regional and strain differences in rat brain sialic acid and 2-deoxyribose.
19651189 - Activation of retinal stem cells in the proliferating marginal region of rcs rats durin...
3682019 - Mucus protection and airway peroxidation following nitrogen dioxide exposure in the rat.
6699819 - Effects of prazosin on fertility of male rats.
9206329 - Radioautographic study of the incorporation of (3h)-choline into the phospholipids of s...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine and biology     Volume:  27     ISSN:  0969-8051     ISO Abbreviation:  Nucl. Med. Biol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-15     Completed Date:  2001-01-11     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9304420     Medline TA:  Nucl Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  617-25     Citation Subset:  IM    
Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Sydney, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / metabolism,  radionuclide imaging*
Carrier Proteins / metabolism
Cerebellum / metabolism,  radionuclide imaging
Cocaine / analogs & derivatives*,  pharmacokinetics
Computer Simulation*
Corpus Striatum / metabolism,  radionuclide imaging
Dopamine Antagonists / pharmacokinetics
Dopamine Plasma Membrane Transport Proteins
Dose-Response Relationship, Drug
Image Processing, Computer-Assisted
Membrane Glycoproteins*
Membrane Transport Proteins*
Models, Neurological*
Nerve Tissue Proteins*
Phantoms, Imaging
Raclopride / pharmacokinetics
Radioisotopes / pharmacokinetics
Receptors, Dopamine D2 / antagonists & inhibitors
Reproducibility of Results
Sensitivity and Specificity
Tomography, Emission-Computed / methods*,  standards
Reg. No./Substance:
0/Carrier Proteins; 0/Dopamine Antagonists; 0/Dopamine Plasma Membrane Transport Proteins; 0/Ligands; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/Radioisotopes; 0/Receptors, Dopamine D2; 146145-21-3/RTI 121; 50-36-2/Cocaine; 84225-95-6/Raclopride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Biological energy from the igneous rock enhances cell growth and enzyme activity.
Next Document:  Column-switching HPLC for the analysis of plasma in PET imaging studies.