Document Detail


The influence of tomograph sensitivity on kinetic parameter estimation in positron emission tomography imaging studies of the rat brain.
MedLine Citation:
PMID:  11056379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the influence of tomograph sensitivity on reliability of parameter estimation in positron emission tomography studies of the rat brain. The kinetics of two tracers in rat striatum and cerebellum were simulated. A typical injected dose of 10 MBq and a reduced dose of 1 MBq were assumed. Kinetic parameters were estimated using a region of interest (ROI) analysis and two pixel-by-pixel analyses. Striatal binding potential was estimated as a function of effective tomograph sensitivity (S(eff)) using a simplified reference tissue model. A S(eff) value of > or =1% was required to ensure reliable parameter estimation for ROI analysis and a S(eff) of 3-6% was required for pixel-by-pixel analysis. We conclude that effective tomograph sensitivity of 3% may be an appropriate design goal for rat brain imaging.
Authors:
S R Meikle; S Eberl; R R Fulton; M Kassiou; M J Fulham
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine and biology     Volume:  27     ISSN:  0969-8051     ISO Abbreviation:  Nucl. Med. Biol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-15     Completed Date:  2001-01-11     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9304420     Medline TA:  Nucl Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  617-25     Citation Subset:  IM    
Affiliation:
Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Sydney, Australia. steve@nucmed.rpa.cs.nsw.gov.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism,  radionuclide imaging*
Carrier Proteins / metabolism
Cerebellum / metabolism,  radionuclide imaging
Cocaine / analogs & derivatives*,  pharmacokinetics
Computer Simulation*
Corpus Striatum / metabolism,  radionuclide imaging
Dopamine Antagonists / pharmacokinetics
Dopamine Plasma Membrane Transport Proteins
Dose-Response Relationship, Drug
Image Processing, Computer-Assisted
Ligands
Membrane Glycoproteins*
Membrane Transport Proteins*
Models, Neurological*
Nerve Tissue Proteins*
Phantoms, Imaging
Raclopride / pharmacokinetics
Radioisotopes / pharmacokinetics
Rats
Receptors, Dopamine D2 / antagonists & inhibitors
Reproducibility of Results
Sensitivity and Specificity
Tomography, Emission-Computed / methods*,  standards
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Dopamine Antagonists; 0/Dopamine Plasma Membrane Transport Proteins; 0/Ligands; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/Radioisotopes; 0/Receptors, Dopamine D2; 146145-21-3/RTI 121; 50-36-2/Cocaine; 84225-95-6/Raclopride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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