| The influence of thymic and bursal lymphoid systems in avian tuberculosis. | |
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MedLine Citation:
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PMID: 5104899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intact and immunologically deficient chickens inoculated with M avium were examined for structural changes in the spleen, the tuberculin reactions and antibody formation. Intravenous inoculation caused miliary tuberculosis of spleen and liver but not brain; intracerebral inoculation caused massive lymphocytic tuberculosis meningitis with later spread to spleen and liver. Neonatal bursectomy and thymectomy did not significantly alter the disease in terms of survival and lesion structure. Cortisone induced earlier development of lesions.In spleen, bacilli were first seen 5 days after inoculation in macrophages in the lymphoid sheath-particularly in capsules of germinal centers. Subsequent lesions were tubercles in the lymphoid sheath, hyperplasia of penicillar arteriolar sheaths, lymphoid atrophy and amyloid deposition. Tubercles were composed of infected macrophages located centrally and surrounded by lighter noninfected macrophages. Cell membranes were extensively interwined where these cells were in contact. Mycobacteria were present within dense, membrane-bound residual bodies.Antibody was first detected 8 days after inoculation in intact birds and persisted throughout the disease. Tuberculin reactions were mixtures of a perivascular monocytic response (delayed hypersensitivity) which developed early and was absent terminally, and a vasculonecrotic response which developed later and persisted to death of the bird. Both reactions occurred in the absence of detectable antibody in bursectomized birds. |
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Authors:
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N F Cheville; W D Richards |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of pathology Volume: 64 ISSN: 0002-9440 ISO Abbreviation: Am. J. Pathol. Publication Date: 1971 Jul |
Date Detail:
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Created Date: 1971-09-02 Completed Date: 1971-09-02 Revised Date: 2010-06-22 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 97-122 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation Brain / immunology Bursa of Fabricius / immunology* Cell Membrane Chickens Hypersensitivity, Delayed Immunity, Cellular Immunoelectrophoresis Immunosuppression Macrophages / immunology Mycobacterium / immunology Poultry Diseases / immunology* Spleen / immunology* Thymus Gland / immunology* Tuberculin Test Tuberculosis, Avian / immunology* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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