Document Detail

The influence of target and patient characteristics on the volume obtained from cone beam CT in lung stereotactic body radiation therapy.
MedLine Citation:
PMID:  23395064     Owner:  NLM     Status:  Publisher    
PURPOSE: To investigate the influence of tumor and patient characteristics on the target volume obtained from cone beam CT (CBCT) in lung stereotactic body radiation therapy (SBRT). MATERIALS AND METHODS: For a given cohort of 71 patients, the internal target volume (ITV) in CBCT obtained from four different datasets was compared with a reference ITV drawn on a four-dimensional CT (4DCT). The significance of the tumor size, location, relative target motion (RM) and patient's body mass index (BMI) and gender on the adequacy of ITV obtained from CBCT was determined. RESULTS: The median ITV-CBCT was found to be smaller than the ITV-4DCT by 11.8% (range: -49.8 to +24.3%, P<0.001). Small tumors located in the lower lung were found to have a larger RM than large tumors in the upper lung. Tumors located near the central lung had high CT background which reduced the target contrast near the edges. Tumor location close to center vs. periphery was the only significant factor (P=0.046) causing underestimation of ITV in CBCT, rather than RM (P=0.323) and other factors. CONCLUSIONS: The current clinical study has identified that the location of tumor is a major source of discrepancy between ITV-CBCT and ITV-4DCT for lung SBRT.
Hong-Wei Liu; Rao Khan; Rafael D'Ambrosi; Krista Krobutschek; Zoann Nugent; Harold Lau
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-7
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  -     ISSN:  1879-0887     ISO Abbreviation:  Radiother Oncol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Department of Radiation Oncology, Tom Baker Cancer Center, University of Calgary, Canada. Electronic address:
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