Document Detail


The influence of sympathetic nerves on transcutaneous oxygen tension in normal and ischemic lower extremities.
MedLine Citation:
PMID:  3592297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors evaluated the relationship between sympathetic nerve activity and transcutaneous oxygen tension (TcpO2) in normal and ischemic lower extremities. Dorsal foot TcpO2 was measured by using oxygen-sensing electrodes with surface temperatures of 42 degrees C and 45 degrees C; in theory, changes in sympathetic activity should affect vasomotor tone and TcpO2 in skin beneath an electrode at 42 degrees C (submaximal vasodilation), but not at 45 degrees C (maximal vasodilation). The vasodilation index (TcpO2 at 42 degrees C/TcpO2 at 45 degrees C) was created as an index of vasomotor tone (vasodilation index increases as tone decreases). In normal limbs (n = 24) averages for TcpO2 at 42 degrees C, TcpO2 at 45 degrees C, and vasodilation index were 30.3 mmHg, 62.1 mmHg, and 0.47, respectively. In subjects (n = 5) with quadriplegia and reduced sympathetic tone secondary to cervical cord trauma, TcpO2 at 42 degrees C and vasodilation index were increased (45.0 mmHg and 0.61); TcpO2 at 45 degrees C did not change. When normal subjects (n = 7) were chilled for twenty minutes with a cooling blanket at 5 degrees C (to increase sympathetic tone) average vasodilation index dropped from 0.50 to 0.29. Among ischemic limbs (n = 34) vasodilation index was highly variable (range: 0-0.77); in general, vasodilation index fell as the ischemia worsened. In a subset of patients with ischemic limbs, the vasodilation index increased after the limb was wrapped in a warm dressing (average vasodilation index = 0.25 without dressing, 0.37 with dressing). The authors conclude: TcpO2 can be used to assess the degree of vasomotor tone (and sympathetic activity) in skin; tone generally increases as ischemia worsens; and local warmth can improve cutaneous circulation in ischemic limbs.
Authors:
T W Rooke; L H Hollier; P J Osmundson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Angiology     Volume:  38     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-07-07     Completed Date:  1987-07-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  400-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cold Temperature / diagnostic use
Electrodes
Hot Temperature / diagnostic use
Humans
Ischemia / physiopathology*
Leg / blood supply*
Oxygen Consumption*
Skin / blood supply,  metabolism*
Skin Temperature
Spinal Cord Injuries / physiopathology
Sympathetic Nervous System / physiology*
Vasodilation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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