| The influence of steroid hormones on the uterine cervix during pregnancy. | |
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MedLine Citation:
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PMID: 3320546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper reviews the evidence concerning the actions of steroid hormones on the connective tissues of the pelvis. Most available data concern the effects of steroids on the cervix. The time course of cervical softening in rats, sheep and humans suggests the possibility that the changes in connective tissue biochemistry that underlie the physiological phenomenon of cervical softening are under hormonal control. Both oestrogens and progestogens have been implicated in the control of cervical softening. However, recent experiments using inhibitors of 3 beta-hydroxysteroid dehydrogenase suggest that cervical softening can be produced in both sheep and humans by progesterone withdrawal in the absence of high circulating concentrations of oestradiol-17 beta. |
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Authors:
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W L Ledger; A B Anderson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of steroid biochemistry Volume: 27 ISSN: 0022-4731 ISO Abbreviation: J. Steroid Biochem. Publication Date: 1987 |
Date Detail:
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Created Date: 1988-02-25 Completed Date: 1988-02-25 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0260125 Medline TA: J Steroid Biochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1029-34 Citation Subset: IM |
Affiliation:
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Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxysteroid Dehydrogenases
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antagonists & inhibitors Animals Cervix Uteri / physiology* Estrogens / physiology* Female Humans Pregnancy / physiology* Progesterone / physiology Progestins / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Progestins; 57-83-0/Progesterone; EC 1.1.-/3-Hydroxysteroid Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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