Document Detail

The influence of solid lipid nanoparticles on skin hydration and viscoelasticity--in vivo study.
MedLine Citation:
PMID:  12837483     Owner:  NLM     Status:  MEDLINE    
Effects on skin hydration and viscoelasticity are important criteria during the development of novel cosmetic formulations. This study focuses on the in vivo performance of a conventional o/w cream and of the same cream enriched with solid lipid nanoparticles (SLN). Influences on skin hydration and viscoelastic properties were investigated with validated devices (Corneometer and Cutometer). After an application period of 4 weeks, significant changes in skin hydration were detected for both formulations. The SLN-enriched cream was significantly more effective than the conventional cream (+24% for the cream and +31% for the SLN-cream). The viscoelastic parameters UF and UA/UF remained almost unchanged, which is attributed to the young age of the volunteers. At this stage, SLN represent a promising compound for hydrating new cosmetic formulations.
Sylvia A Wissing; Rainer H Müller
Related Documents :
10874003 - Retinoids in chemoprevention and differentiation therapy.
12414803 - Rosiglitazone and retinoic acid induce uncoupling protein-1 (ucp-1) in a p38 mitogen-ac...
10993233 - Convenient synthesis of alpha-trifluoromethylated acyloins from alpha-hydroxy or alpha-...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V     Volume:  56     ISSN:  0939-6411     ISO Abbreviation:  Eur J Pharm Biopharm     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-02     Completed Date:  2004-02-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9109778     Medline TA:  Eur J Pharm Biopharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
Department of Pharmaceutics, Biopharmaceutics and Biotechnology, The Free University of Berlin, Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Topical
Calorimetry, Differential Scanning
Chemistry, Pharmaceutical
Cosmetics / administration & dosage,  chemistry,  pharmacology*
Lipids / administration & dosage,  chemistry,  pharmacology*
Particle Size
Skin Physiological Phenomena / drug effects*
Time Factors
Water / chemistry
Reg. No./Substance:
0/Cosmetics; 0/Lipids; 0/Ointments; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Skin protection against ultraviolet induced free radicals with ascorbyl palmitate in microemulsions.
Next Document:  Influence of n-octenylsuccinate starch on in vitro permeation of sodium diclofenac across excised po...