Document Detail


The influence of solid lipid nanoparticles on skin hydration and viscoelasticity--in vivo study.
MedLine Citation:
PMID:  12837483     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects on skin hydration and viscoelasticity are important criteria during the development of novel cosmetic formulations. This study focuses on the in vivo performance of a conventional o/w cream and of the same cream enriched with solid lipid nanoparticles (SLN). Influences on skin hydration and viscoelastic properties were investigated with validated devices (Corneometer and Cutometer). After an application period of 4 weeks, significant changes in skin hydration were detected for both formulations. The SLN-enriched cream was significantly more effective than the conventional cream (+24% for the cream and +31% for the SLN-cream). The viscoelastic parameters UF and UA/UF remained almost unchanged, which is attributed to the young age of the volunteers. At this stage, SLN represent a promising compound for hydrating new cosmetic formulations.
Authors:
Sylvia A Wissing; Rainer H Müller
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V     Volume:  56     ISSN:  0939-6411     ISO Abbreviation:  Eur J Pharm Biopharm     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-02     Completed Date:  2004-02-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9109778     Medline TA:  Eur J Pharm Biopharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, Biopharmaceutics and Biotechnology, The Free University of Berlin, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Calorimetry, Differential Scanning
Chemistry, Pharmaceutical
Cosmetics / administration & dosage,  chemistry,  pharmacology*
Elasticity
Female
Humans
Lipids / administration & dosage,  chemistry,  pharmacology*
Nanotechnology
Ointments
Particle Size
Skin Physiological Phenomena / drug effects*
Time Factors
Water / chemistry
Chemical
Reg. No./Substance:
0/Cosmetics; 0/Lipids; 0/Ointments; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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