Document Detail

The influence of smoking and of oral and transdermal nicotine on blood pressure, and haematology and coagulation indices.
MedLine Citation:
PMID:  9308759     Owner:  NLM     Status:  MEDLINE    
Nicotine is helpful in stopping smoking but its influence on cardiovascular risk factors is incomplete. Our aim was to determine its effect on blood pressure, routine haematology indices, and coagulation indices relevant to thrombosis. Eighteen subjects were seen whilst smoking (cotinine levels 1119 +/- 414 ng/ml), again after stopping smoking but while using nicotine chewing gum and/or skin patches (392 +/- 198 ng/ml), and again when not using nicotine (cotinine undetectable). There were no significant changes in blood pressures, platelet count, mean platelet volume, viscosity or anti-thrombin III. However, white blood cell count (p = 0.003), lymphocyte count (p = 0.016), red blood cell count (p = 0.02), haemoglobin (p <0.001), fibrinogen (p <0.001) and von Willebrand factor (p = 0.001) all fell between the first and second samples (when still using nicotine) but not between the second and third samples (when off nicotine). Oral and/or transdermal nicotine does not influence blood pressure or the haematology and coagulation indices we have measured.
A D Blann; C Steele; C N McCollum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  78     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-01-14     Completed Date:  1998-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1093-6     Citation Subset:  IM    
University Department of Medicine, The City Hospital, Birmingham, UK.
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MeSH Terms
Administration, Cutaneous
Administration, Oral
Blood Coagulation / drug effects*
Blood Pressure / drug effects*
Hematologic Tests
Middle Aged
Nicotine / administration & dosage,  pharmacology*
Reg. No./Substance:

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