| The influence of smoking and of oral and transdermal nicotine on blood pressure, and haematology and coagulation indices. | |
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MedLine Citation:
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PMID: 9308759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nicotine is helpful in stopping smoking but its influence on cardiovascular risk factors is incomplete. Our aim was to determine its effect on blood pressure, routine haematology indices, and coagulation indices relevant to thrombosis. Eighteen subjects were seen whilst smoking (cotinine levels 1119 +/- 414 ng/ml), again after stopping smoking but while using nicotine chewing gum and/or skin patches (392 +/- 198 ng/ml), and again when not using nicotine (cotinine undetectable). There were no significant changes in blood pressures, platelet count, mean platelet volume, viscosity or anti-thrombin III. However, white blood cell count (p = 0.003), lymphocyte count (p = 0.016), red blood cell count (p = 0.02), haemoglobin (p <0.001), fibrinogen (p <0.001) and von Willebrand factor (p = 0.001) all fell between the first and second samples (when still using nicotine) but not between the second and third samples (when off nicotine). Oral and/or transdermal nicotine does not influence blood pressure or the haematology and coagulation indices we have measured. |
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Authors:
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A D Blann; C Steele; C N McCollum |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 78 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1998-01-14 Completed Date: 1998-01-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: GERMANY |
Other Details:
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Languages: eng Pagination: 1093-6 Citation Subset: IM |
Affiliation:
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University Department of Medicine, The City Hospital, Birmingham, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Administration, Oral Adult Blood Coagulation / drug effects* Blood Pressure / drug effects* Female Hematologic Tests Humans Male Middle Aged Nicotine / administration & dosage, pharmacology* Smoking* |
| Chemical | |
Reg. No./Substance:
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54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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