Document Detail


The influence of slice orientation on brain MRI lesion load measurement in multiple sclerosis.
MedLine Citation:
PMID:  9493638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study aimed at evaluating the influence of a different slice orientation on brain magnetic resonance imaging (MRI) lesion load in multiple sclerosis (MS). Fifteen MS patients were scanned obtaining both axial and sagittal conventional spin echo (24 slices; TR 2400, TE 30/80) brain MRI. The total lesion load (TLL) was assessed twice for each scan, using a semi-automated local thresholding technique and the same marked hardcopies. The mean TLL was 22734 mm3 for axial and 22003 mm3 for sagittal scans. The mean intra-observer coefficient of variation (COV) was 4.65% for the axial acquisitions and 4.52% for the sagittal acquisitions. This difference was not statistically significant (one-way ANOVA, P > 0.1). The lesion load was significantly higher from axial MRI as compared to the intra-observer variability (two-way ANOVA, P=0.01), but the fluctuations around this average difference between axial and sagittal scan TLL were significantly large (test for interaction, P < 0.001). Our data indicate that the use of sagittal conventional MRI scans does not seem to be worthwhile for the quantitative assessment of lesion load in MS patients.
Authors:
M Rovaris; M P Sormani; M A Rocca; G Comi; M Filippi
Related Documents :
15955278 - Ms across continents: challenging our knowledge of ms in asia and the middle east. repo...
8836938 - A spinal cord mri study of benign and secondary progressive multiple sclerosis.
20813778 - Composite mri scores improve correlation with edss in multiple sclerosis.
15007138 - Mri criteria for multiple sclerosis: evaluation in a pediatric cohort.
23115368 - Diverticulum of the third ventricle and absence of the interthalamic adhesion in a dog.
23971168 - Whole body pet-ct: m staging in non small-cell lung cancer.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  3     ISSN:  1352-4585     ISO Abbreviation:  Mult. Scler.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-04-02     Completed Date:  1998-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  382-4     Citation Subset:  IM    
Affiliation:
MS Biosignal Analysis Center, Department of Neurology, IRCCS Ospedale San Raffaele, University of Milan, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Brain / pathology*
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Multiple Sclerosis / diagnosis*
Observer Variation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification of a Val 145 Ile substitution in the human myelin oligodendrocyte glycoprotein: lack ...
Next Document:  The birth and development of the forced expiratory manoeuvre: a tribute to Robert Tiffeneau (1910-19...