Document Detail

The influence of slice orientation on brain MRI lesion load measurement in multiple sclerosis.
MedLine Citation:
PMID:  9493638     Owner:  NLM     Status:  MEDLINE    
This study aimed at evaluating the influence of a different slice orientation on brain magnetic resonance imaging (MRI) lesion load in multiple sclerosis (MS). Fifteen MS patients were scanned obtaining both axial and sagittal conventional spin echo (24 slices; TR 2400, TE 30/80) brain MRI. The total lesion load (TLL) was assessed twice for each scan, using a semi-automated local thresholding technique and the same marked hardcopies. The mean TLL was 22734 mm3 for axial and 22003 mm3 for sagittal scans. The mean intra-observer coefficient of variation (COV) was 4.65% for the axial acquisitions and 4.52% for the sagittal acquisitions. This difference was not statistically significant (one-way ANOVA, P > 0.1). The lesion load was significantly higher from axial MRI as compared to the intra-observer variability (two-way ANOVA, P=0.01), but the fluctuations around this average difference between axial and sagittal scan TLL were significantly large (test for interaction, P < 0.001). Our data indicate that the use of sagittal conventional MRI scans does not seem to be worthwhile for the quantitative assessment of lesion load in MS patients.
M Rovaris; M P Sormani; M A Rocca; G Comi; M Filippi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  3     ISSN:  1352-4585     ISO Abbreviation:  Mult. Scler.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-04-02     Completed Date:  1998-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  382-4     Citation Subset:  IM    
MS Biosignal Analysis Center, Department of Neurology, IRCCS Ospedale San Raffaele, University of Milan, Italy.
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MeSH Terms
Brain / pathology*
Magnetic Resonance Imaging / methods*
Middle Aged
Multiple Sclerosis / diagnosis*
Observer Variation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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