| The influence of slice orientation on brain MRI lesion load measurement in multiple sclerosis. | |
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MedLine Citation:
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PMID: 9493638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed at evaluating the influence of a different slice orientation on brain magnetic resonance imaging (MRI) lesion load in multiple sclerosis (MS). Fifteen MS patients were scanned obtaining both axial and sagittal conventional spin echo (24 slices; TR 2400, TE 30/80) brain MRI. The total lesion load (TLL) was assessed twice for each scan, using a semi-automated local thresholding technique and the same marked hardcopies. The mean TLL was 22734 mm3 for axial and 22003 mm3 for sagittal scans. The mean intra-observer coefficient of variation (COV) was 4.65% for the axial acquisitions and 4.52% for the sagittal acquisitions. This difference was not statistically significant (one-way ANOVA, P > 0.1). The lesion load was significantly higher from axial MRI as compared to the intra-observer variability (two-way ANOVA, P=0.01), but the fluctuations around this average difference between axial and sagittal scan TLL were significantly large (test for interaction, P < 0.001). Our data indicate that the use of sagittal conventional MRI scans does not seem to be worthwhile for the quantitative assessment of lesion load in MS patients. |
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Authors:
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M Rovaris; M P Sormani; M A Rocca; G Comi; M Filippi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 3 ISSN: 1352-4585 ISO Abbreviation: Mult. Scler. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-04-02 Completed Date: 1998-04-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 382-4 Citation Subset: IM |
Affiliation:
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MS Biosignal Analysis Center, Department of Neurology, IRCCS Ospedale San Raffaele, University of Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / pathology* Female Humans Magnetic Resonance Imaging / methods* Male Middle Aged Multiple Sclerosis / diagnosis* Observer Variation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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