Document Detail

The influence of sex on right ventricular dysfunction in patients with severely depressed left ventricular ejection fraction.
MedLine Citation:
PMID:  16504576     Owner:  NLM     Status:  MEDLINE    
AIM: To assess the influence of sex on right ventricular dysfunction (RVD) in patients with severe left ventricular systolic dysfunction.
METHODS AND RESULTS: We studied 385 consecutive patients with left ventricular ejection fraction (LVEF) <0.35. All patients underwent invasive measurement of right ventricular and pulmonary artery pressures and evaluation of RVD by standard transthoracic echocardiography. Female patients (n=84, 21.8%) were significantly older than male patients (62.0+/-11.4 vs. 58.2+/-10.7 years), p=0.005. The prevalence of RVD was lower in women (26.5%) than in men (38.9%), p=0.03; both in patients with and without coronary artery disease (19.4% vs. 34.5% and 31.9% vs. 44.4%, respectively). Haemodynamic parameters and LVEF were similar in men and women. Low LVEF, pulmonary systolic pressure, degree of mitral regurgitation, male sex, and absence of significant coronary artery disease were independently correlated with RVD.
CONCLUSION: Women with severe left ventricular systolic dysfunction have less RVD than men, despite similar haemodynamic parameters and LVEF.
Manuel Martínez-Sellés; Marta Domínguez Muñoa; Esther Martínez; Miguel Angel García Fernández; Eulogio García
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Publication Detail:
Type:  Journal Article     Date:  2006-02-28
Journal Detail:
Title:  European journal of heart failure     Volume:  8     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-11-01     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  400-3     Citation Subset:  IM    
Cardiology Department. Hospital Universitario Gregorio Marañón, Dr. Esquerdo, 46. 28007 Madrid, Spain.
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MeSH Terms
Aged, 80 and over
Middle Aged
Sex Factors*
Ventricular Dysfunction, Left / physiopathology*
Ventricular Dysfunction, Right / physiopathology*

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