Document Detail

The influence of semistarvation-induced hyperactivity on hypothalamic serotonin metabolism.
MedLine Citation:
PMID:  1720894     Owner:  NLM     Status:  MEDLINE    
Male rats kept in a running wheel developed hyperactivity when food was restricted. Highest activity occurred around noon when food was given. Semistarved sedentary and ad lib fed sedentary and running rats served as controls. Five-hydroxyindole-acetic acid (5-HIAA) in the medial basal hypothalamus was lowest in the sedentary ad lib fed group. Running significantly increased 5-HIAA. Starvation likewise increased 5-HIAA. This effect was further enhanced by hyperactivity. When the circadian rhythm of serotonin (5-HT) and 5-HIAA was studied in the hypothalamus, a minimum of 5-HT as seen in semistarved sedentary and running rats around feeding time (noon). At this time 5-HIAA reached a maximum in the semistarved running rats while semistarved sedentary and ad lib fed rats showed no circadian pattern of 5-HIAA. These data indicate that serotonin turnover in the medial basal hypothalamus is increased as a consequence of semistarvation and hyperactivity.
A Broocks; U Schweiger; K M Pirke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  50     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-01-13     Completed Date:  1992-01-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  385-8     Citation Subset:  IM    
Division of Psychoneuroendocrinology, Max Planck Institut for Psychiatry, München, F.R. Germany.
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MeSH Terms
Fasting / physiology*
Hydroxyindoleacetic Acid / metabolism
Hypothalamus / physiology*
Hypothalamus, Middle / physiology
Motor Activity / physiology*
Preoptic Area / physiology
Serotonin / metabolism*
Reg. No./Substance:
50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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