| The influence of sectional interval on the reliability of temporal arterial biopsies in polymyalgia rheumatica. | |
| | |
MedLine Citation:
|
PMID: 7641512 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Temporal arterial biopsies from 27 patients with a clinical diagnosis of pure polymyalgia rheumatica (PMR) were examined using light microscopy on paraffin and plastic sections. The primary routine examination of the paraffin-embedded parts of the biopsies (biopsy length: 12.7 +/- 4.5 mm, sub-segments: 4.9 +/- 1.2 mm) revealed 4 positive cases, whereas the primary examination of the smaller plastic-embedded parts showed inflammation in 6 cases (biopsy length: 2.7 +/- 1.2 mm, sub-segments: 0.7 +/- 0.3 mm). Serial sectioning with a 50 microns interval of arteries which were negative primarily revealed three new positive cases in the paraffin-embedded material (total length: 174.0 mm), whereas sectioning the plastic-embedded material (total length: 52.8 mm) produced one more positive artery. All the new cases displayed a focal inflammatory process in atrophic, calcified arterial segments. The high yield of positive biopsies in the present material (11 of 27; 40.7%) demonstrates the diagnostic value of temporal arterial biopsy in PMR and the importance of a careful histologic examination. The results also indicate the influence of biopsy length on the yield of positive biopsies. The division of fixed temporal arterial biopsies into approximately 1-mm-long sub-segments before the embedding and the further serial sectioning of those negative biopsies which are atrophic and/or calcified is recommended in cases of pure PMR. |
| | |
Authors:
|
E Nordborg; C Nordborg |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical rheumatology Volume: 14 ISSN: 0770-3198 ISO Abbreviation: Clin. Rheumatol. Publication Date: 1995 May |
Date Detail:
|
Created Date: 1995-09-21 Completed Date: 1995-09-21 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8211469 Medline TA: Clin Rheumatol Country: BELGIUM |
Other Details:
|
Languages: eng Pagination: 330-4 Citation Subset: IM |
Affiliation:
|
Dept of Rheumatology, Sahlgren's University Hospital, Göteborg, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Atrophy Biopsy / methods* Calcinosis / pathology Evaluation Studies as Topic Female Humans Male Middle Aged Paraffin Embedding Plastic Embedding Polymyalgia Rheumatica / pathology* Predictive Value of Tests Temporal Arteries / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ultrasound-guided aspiration in suspected sepsis of resection arthroplasty of the hip joint.
Next Document: Systemic lupus erythematosus in Saudi patients.