Document Detail

The influence of repeated administration of prazosin on its hypotensive effect and on renin release in conscious dogs. A comparison with urapidil.
MedLine Citation:
PMID:  6391463     Owner:  NLM     Status:  MEDLINE    
The effects of prazosin (0.1, 0.5 and 2.5 mg/kg, orally) on blood pressure, heart rate and PRA were investigated after acute and chronic administration in conscious, normotensive dogs. The acute administration of prazosin caused a reduction in both systolic and diastolic blood pressure and an increase in heart rate and PRA. After chronic administration, twice daily for four days, tolerance developed, which was not due to persistent counterregulation. On comparison with urapidil, another alpha-adrenoceptor antagonist, the hypotensive and counterregulatory response to acute administration were similar with both substances; the development of tolerance to prazosin after chronic administration contrasted with the results with urapidil.
A Beck; O Kraupp; S Bacher; R Seitelberger; G Raberger
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  79     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1984 Sep-Oct
Date Detail:
Created Date:  1985-01-22     Completed Date:  1985-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  579-87     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Heart Rate / drug effects
Piperazines / pharmacology*
Prazosin / pharmacology*
Quinazolines / pharmacology*
Renin / blood*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Piperazines; 0/Quinazolines; 19216-56-9/Prazosin; 34661-75-1/urapidil; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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