| The influence of raw and processed garlic and onions on plasma classical and non-classical atherosclerosis indices: investigations in vitro and in vivo. | |
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MedLine Citation:
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PMID: 19827019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Garlic and white and red varieties of onion were subjected to processing by a variety of culinary methods, and bioactive compounds then determined. For in vivo studies, 84 male Wistar rats were randomly divided into 14 diet groups, each of six rats, including two control groups (one with no supplementation and one with cholesterol supplementation only). During the 30-day trial, the basal diets of the other 12 groups were supplemented with 1% cholesterol and raw or processed vegetables. Both raw red onion and red onion subjected to blanching for 90 s hindered the rise in plasma lipids more than the other vegetables studied in the supplemented diets. The decrease in antioxidant activity compared to the cholesterol-supplemented control group was significantly less for the group fed with red onion subjected to blanching for 90 s. No histological changes were detected in the studied organs of rats that had been fed cholesterol. In conclusion, blanching for 90 s most fully preserved the bioactive compounds and antioxidant potentials, and hindered the rise in plasma lipid levels and the decrease in plasma antioxidant activity of rats fed cholesterol. Alkaline phosphatase levels correlated with classical atherosclerosis indices, and determination of alkaline phosphatase is suggested as an additional index in atherosclerosis testing. |
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Authors:
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Shela Gorinstein; Hanna Leontowicz; Maria Leontowicz; Zenon Jastrzebski; Katarzyna Najman; Zev Tashma; Elena Katrich; Buk-Gu Heo; Ja-Yong Cho; Yun-Jum Park; Simon Trakhtenberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 24 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 706-14 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Medicinal Chemistry and Natural Products, School of Pharmacy, the Hebrew University, Hadassah Medical School, Jerusalem, Israel. gorin@cc.huji.ac.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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blood Animals Antioxidants / analysis Atherosclerosis Cholesterol, Dietary / administration & dosage Diet, Atherogenic* Food Handling / methods Garlic* Lipids / blood* Male Onions* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Cholesterol, Dietary; 0/Lipids; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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