Document Detail

The influence of raw and processed garlic and onions on plasma classical and non-classical atherosclerosis indices: investigations in vitro and in vivo.
MedLine Citation:
PMID:  19827019     Owner:  NLM     Status:  MEDLINE    
Garlic and white and red varieties of onion were subjected to processing by a variety of culinary methods, and bioactive compounds then determined. For in vivo studies, 84 male Wistar rats were randomly divided into 14 diet groups, each of six rats, including two control groups (one with no supplementation and one with cholesterol supplementation only). During the 30-day trial, the basal diets of the other 12 groups were supplemented with 1% cholesterol and raw or processed vegetables. Both raw red onion and red onion subjected to blanching for 90 s hindered the rise in plasma lipids more than the other vegetables studied in the supplemented diets. The decrease in antioxidant activity compared to the cholesterol-supplemented control group was significantly less for the group fed with red onion subjected to blanching for 90 s. No histological changes were detected in the studied organs of rats that had been fed cholesterol. In conclusion, blanching for 90 s most fully preserved the bioactive compounds and antioxidant potentials, and hindered the rise in plasma lipid levels and the decrease in plasma antioxidant activity of rats fed cholesterol. Alkaline phosphatase levels correlated with classical atherosclerosis indices, and determination of alkaline phosphatase is suggested as an additional index in atherosclerosis testing.
Shela Gorinstein; Hanna Leontowicz; Maria Leontowicz; Zenon Jastrzebski; Katarzyna Najman; Zev Tashma; Elena Katrich; Buk-Gu Heo; Ja-Yong Cho; Yun-Jum Park; Simon Trakhtenberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  24     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  706-14     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 John Wiley & Sons, Ltd.
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, the Hebrew University, Hadassah Medical School, Jerusalem, Israel.
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MeSH Terms
Alkaline Phosphatase / blood
Antioxidants / analysis
Cholesterol, Dietary / administration & dosage
Diet, Atherogenic*
Food Handling / methods
Lipids / blood*
Rats, Wistar
Reg. No./Substance:
0/Antioxidants; 0/Cholesterol, Dietary; 0/Lipids; EC Phosphatase

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