Document Detail

The influence of prostacyclin on the recovery of bioelectric cerebral activity after complete ischemia.
MedLine Citation:
PMID:  3513477     Owner:  NLM     Status:  MEDLINE    
Complete cerebral ischemia (CCI) was evoked by closing the brachiocephalic trunk, the left subclavicular artery and both internal thoracic arteries with simultaneous depression of systemic arterial pressure (SAP) to 70-50 mm Hg. The experiments were performed with three groups of rabbits. The first group consisted of animals with 15 and 20 min CCI, not receiving PGI2. In the second group PGI2 was given for 15 min before and during 15 min CCI. The third group with 15 and 20 min CCI received PGI2 3 min before, during and for 15 min after ischemia. The recovery of ECoG and the activities of the respiratory and vasomotor centres were evaluated as were reflex reactions. In 38 percent of the second group of rabbits improvement of the neurological condition after CCI was noted, as compared with animals of the control groups and a faster recovery of the ECoG. In the third group the neurological state improved in 100 percent of cases with simultaneous significantly quicker recovery of the first symptoms of brain cortex bioelectric activity and continuous activity in ECoG records. Between groups 1 and 2, and group 3 there were differences concerning the time of recovery of ECoG, and the intensity of reflexes. The influence of PGI2 on the brain bioelectric activity of the animals after CCI was found to be favourable.
R Pluta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  73     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-14     Completed Date:  1986-04-14     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  44-54     Citation Subset:  IM    
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MeSH Terms
Cerebral Cortex / drug effects,  physiopathology*
Cerebrovascular Circulation
Epoprostenol / pharmacology*
Ischemic Attack, Transient / physiopathology*
Vasomotor System / physiopathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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