Document Detail


The influence of propofol or desflurane on postoperative cognitive dysfunction in patients undergoing coronary artery bypass surgery*
MedLine Citation:
PMID:  21501129     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We investigated the influence of either propofol or desflurane on the incidence of postoperative cognitive dysfunction in a randomised trial of 180 patients undergoing coronary artery bypass surgery. The primary outcome was incidence of postoperative cognitive dysfunction at 3 months, defined as ≥ 1 SD deterioration in two or more of 12 neurocognitive tests. Secondary outcomes included early postoperative cognitive dysfunction (between days three and seven), delirium on day one, morbidity and length of hospital stay. Early postoperative cognitive dysfunction was significantly higher with propofol compared with desflurane (56/84 (67.5%) vs 41/83 (49.4%), respectively, p = 0.018), but this effect was not seen at 3 months (10/87 (11.2%) vs 9/90 (10.0%), respectively. There was no difference in delirium (7/89 (7.9%) vs 12/91 (13.2%), respectively, length of hospital stay (median (IQR [range]) 7 (6-9 [4-15]) vs 6 (5-7 [5-16) days, respectively or other morbidities. Desflurane was associated with reduced early cognitive dysfunction.
Authors:
C F Royse; D T Andrews; S N Newman; J Stygall; Z Williams; J Pang; A G Royse
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-18
Journal Detail:
Title:  Anaesthesia     Volume:  -     ISSN:  1365-2044     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland.
Affiliation:
 Professor, Anaesthesia and Pain Management Unit, Department of Pharmacology, University of Melbourne, Carlton, Victoria; and Consultant Anaesthetist, Department of Anaesthesia and Pain Management, the Royal Melbourne Hospital, Australia  Consultant Anaesthetist, Department of Anaesthesia and Pain Management, the Royal Melbourne Hospital, and Anaesthesia and Pain Management Unit, Department of Pharmacology, University of Melbourne, Carlton, Victoria, Australia  Professor of Health Psychology and Honorary Consultant, Unit of Behavioural Medicine, University College London, UK, and Dean, Faculty of Health Sciences, City University, London, UK  Senior Research Fellow, Unit of Behavioural Medicine, University College London, UK, and Faculty of Health Sciences, City University, London, UK  Research Manager  Researcher, Anaesthesia and Pain Management Unit, Department of Pharmacology, University of Melbourne, Carlton, Victoria, Australia  Associate Professor, Department of Surgery, University of Melbourne; and Cardiothoracic Surgeon, Department of Cardiac Surgery, The Royal Melbourne Hospital, Australia.
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