Document Detail

The influence of prolonged ACTH treatment on rat adrenal steroidogenesis.
MedLine Citation:
PMID:  185672     Owner:  NLM     Status:  MEDLINE    
A series of in vitro experiments using pregnenolone-14C-4 and progesterone-14C-4 as precursors were performed to determine the effects of prolonged ACTH administration on adrenal steroid biogenesis in the rat. Under ACTH administration there was a tendency for the isolated steroids to have larger quantities and specific activities from both precursors than under control conditions. In contrast to the rabbit, the rat did not produce any detectable amounts of 17 alpha-hydroxylated steroids under either control or prolonged ACTH treatment using the very sensitive double isotope derivative assay for quantitation.
T J Slaga; A A Krum
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  15     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-90     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / drug effects,  metabolism*
Adrenocorticotropic Hormone / pharmacology*
Pregnenolone / metabolism
Progesterone / metabolism
Steroids / biosynthesis*
Time Factors
Reg. No./Substance:
0/Steroids; 145-13-1/Pregnenolone; 57-83-0/Progesterone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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