Document Detail


The influence of prolonged ACTH treatment on rat adrenal steroidogenesis.
MedLine Citation:
PMID:  185672     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of in vitro experiments using pregnenolone-14C-4 and progesterone-14C-4 as precursors were performed to determine the effects of prolonged ACTH administration on adrenal steroid biogenesis in the rat. Under ACTH administration there was a tendency for the isolated steroids to have larger quantities and specific activities from both precursors than under control conditions. In contrast to the rabbit, the rat did not produce any detectable amounts of 17 alpha-hydroxylated steroids under either control or prolonged ACTH treatment using the very sensitive double isotope derivative assay for quantitation.
Authors:
T J Slaga; A A Krum
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  15     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-90     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / drug effects,  metabolism*
Adrenocorticotropic Hormone / pharmacology*
Animals
Male
Pregnenolone / metabolism
Progesterone / metabolism
Rats
Steroids / biosynthesis*
Swine
Time Factors
Chemical
Reg. No./Substance:
0/Steroids; 145-13-1/Pregnenolone; 57-83-0/Progesterone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mitochondrial DNA of Yoshida ascites tumour cells. Physicochemical properties and biological functio...
Next Document:  Systemic stress in the production of cardiac thrombosis in hypercholesterolaemic rats.