Document Detail

The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery.
MedLine Citation:
PMID:  22935445     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Patients undergoing cardiac surgery are at risk for postoperative cognitive dysfunction (POCD). Evaluating preoperative risk factors represents 1 possible way to minimize the postoperative risk of cognitive dysfunction. We investigated marked deterioration in cholinergic neurotransmission as 1 such potential risk factor for transient and long-lasting POCD. Serum anticholinergic activity (SAA) has already been described as a risk factor for developing delirium in an elderly study population. However, the role of SAA for long-lasting POCD is unknown. METHODS: Following local ethics board approval and written informed consent, we recruited a cohort of patients aged ≥ 55 years undergoing cardiac surgery. Before surgery, levels of SAA were measured and a battery of neuropsychologic tests (NPTs) was applied. S100 calcium binding protein ß concentration was measured intraoperatively. Pre-, intra-, and postoperative patient-specific characteristics were recorded. The NPTs were repeated 3 months after hospital discharge to evaluate 3-month POCD. A group of nonsurgical patients (n = 34) was recruited as control subjects to adjust NPT scores, using reliable methods for the change index. Logistic multivariate regression was used to evaluate independent predictors of POCD. RESULTS: One hundred fifty-four patients were screened before surgery, and 117 completed the second NPT. POCD was identified in 25.6% of patients. In contrast to intraoperatively increased S100 calcium binding protein ß, preoperative SAA was not associated with POCD following adjustment for covariates. CONCLUSIONS: Preoperatively increased SAA did not predict POCD 3 months after cardiac surgery.
Konstanze Plaschke; Steffen Hauth; Claudia Jansen; Thomas Bruckner; Christoph Schramm; Matthias Karck; Jürgen Kopitz
Related Documents :
18984255 - Bivalve cartilage inlay myringoplasty: an office-based procedure for closing small to m...
8151165 - Percutaneous peripheral rotational ablation using the rotablator: immediate and mid ter...
24943835 - Never too old for an autogenous dialysis fistula? results of endovascular interventions...
18477945 - Medium-term survival after primary angioplasty for myocardial infarction complicated by...
3958825 - Chronic afterload reduction in infants and children with primary myocardial disease.
17011195 - Knee skin temperature following uncomplicated total knee replacement.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-27
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  -     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  China collaborative study on dialysis: a multi-centers cohort study on cardiovascular diseases in pa...
Next Document:  New ascending aortic aneurysm model in rats reproduces main structural features of degenerative asce...