| The influence of prenatal dexamethasone treatment on urinary excretion of adrenocortical steroids in newborns. | |
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MedLine Citation:
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PMID: 9686811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congenital adrenal hyperplasia due to 21-hydroxylase deficiency suspected in 14 newborns (5 F, 9 M), was treated prenatally with dexamethasone from weeks 7-9 of gestation. The 24 h urinary excretion of selected adrenocortical steroids derived from fetal and definitive adrenal zones was evaluated in these newborns at the age of 3 9 days. Among 11 babies born healthy, in one of six treated until confirmation of male karyotype in gestational weeks 12-17 and in four of five treated until delivery, suppression of fetal adrenal zone steroids was observed, accompanied additionally in three by a diminished excretion of tetrahydrocortisone. In three babies born affected (2 male, 1 female), excretion of 17alpha-hydroxyprogesterone and 21-deoxycortisol metabolites did not differ from 12 affected, age-matched controls, not treated prenatally. However, some influence on suppression of the fetal adrenal zone metabolite 16alpha-hydroxypregnenolone was observed in two newborns treated until delivery. CONCLUSIONS: Heterogeneity in the fetal adrenal response to maternal dexamethasone treatment was confirmed. Suppression of fetal adrenals, especially within the fetal adrenal zone, can be observed in some babies born healthy until at least 1 week after birth. |
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Authors:
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E M Małunowicz; M Ginalska-Malinowska; T E Romer; K Bal |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pediatrics Volume: 157 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-09-22 Completed Date: 1998-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: GERMANY |
Other Details:
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Languages: eng Pagination: 539-43 Citation Subset: IM |
Affiliation:
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Department of Laboratory Diagnostics, The Children's Memorial Health Institute, Warsaw, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Hyperplasia, Congenital*
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prevention & control* Dexamethasone / therapeutic use* Female Fetal Diseases / drug therapy* Glucocorticoids / therapeutic use* Humans Hydroxycorticosteroids / urine* Infant, Newborn Male Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Hydroxycorticosteroids; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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