Document Detail

The influence of pregnancy on heterotopic ossification post-displaced acetabular fractures surgical repair.
MedLine Citation:
PMID:  23335247     Owner:  NLM     Status:  Publisher    
Pregnancy is associated with maternal bone mineral density loss and modulation of calcium metabolism. We hypothesized that pregnancy may decrease the risk of heterotopic ossification (HO) after trauma. This is a single-institution, University of Mississippi Medical Center, retrospective study investigating the effect of pregnancy on the incidence HO after surgical repair (SR) of displaced acetabular fractures. Between January 1998 and 2010, 257 non-pregnant women (Group A) and 16 pregnant women (Group B) were identified. All the non-pregnant women received radiation therapy (RT) ± indomethacin. None of the pregnant women in group B received any prophylaxis. After a median follow-up of 6.6 years the incidence of HO in all patients was 27% (75/273). In Group A, non-pregnant, women who received RT ± indomethacin, 29% developed HO; HO risk was 0.4. In Group B, 16 pregnant patients, only one developed HO (6%); HO risk was 0.06. Thus, the risk of HO appears to be nearly six-fold higher in non-pregnant women despite prophylactic RT ± indomethacin. Our data suggest that pregnancy may be associated with a reduced risk of HO after SR of displaced acetabular fractures. Further analysis with a larger pregnant patient sample is necessary to confirm this finding. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.
Waleed F Mourad; Satya Packianathan; Rania A Shourbaji; Richard Jennelle; Claus Chunli Yang; Paul Mobit; Zhen Zhang; Majid A Khan; Mathew Graves; George Russell; Srinivasan Vijayakumar
Related Documents :
25005857 - Risk factors associated with a new pregnancy loss and perinatal outcomes in cases of re...
19113887 - Influences of periodic mechanical deformation on spiral breakup in excitable media.
23943697 - Maternal obesity during pregnancy and premature mortality from cardiovascular event in ...
25021047 - Pmm.48 mother to child transmission (mtct) of hiv: almost a thing of the past?
8288267 - Abo and rhesus blood groups and adverse outcomes of pregnancy.
24639837 - Mitral balloon valvuloplasty during pregnancy:the long term up to 17 years obstetric ou...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  -     ISSN:  1554-527X     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Orthopaedic Research Society.
Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, Mississippi.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and ind...
Next Document:  Monte carlo configuration interaction applied to multipole moments, ionisation energies and electron...