Document Detail

The influence of pregnancy and gender on perivascular innervation of rat posterior cerebral arteries.
MedLine Citation:
PMID:  18497348     Owner:  NLM     Status:  MEDLINE    
The authors investigated the influence of pregnancy and gender on the density of trigeminal and sympathetic perivascular nerves in posterior cerebral arteries (PCA) and the reactivity to norepinephrine and calcitonin gene-related peptide (CGRP). PCAs were isolated from nonpregnant, late-pregnant, postpartum, and male rats, mounted and pressurized on an arteriograph chamber to obtain concentration-response curves to norepinephrine and CGRP. Arteries were immunostained for CGRP-, tyrosine hydroxylase-, and protein gene product 9.5 (PGP 9.5)-containing perivascular nerves, and nerve density was determined morphologically. Pregnancy had a trophic effect on trigeminal perivascular innervation (P < .01 vs male); however, this was not accompanied by a change in reactivity to CGRP. Sympathetic and PGP 9.5 nerve densities were not altered by pregnancy or gender, and there were no differences in reactivity to norepinephrine. Together, these results suggest that the increase in trigeminal innervation during pregnancy is more related to nociception than in controlling resting cerebral blood flow.
Annet M Aukes; Nicole Bishop; Julie Godfrey; Marilyn J Cipolla
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproductive sciences (Thousand Oaks, Calif.)     Volume:  15     ISSN:  1933-7205     ISO Abbreviation:  Reprod Sci     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-23     Completed Date:  2008-07-03     Revised Date:  2013-05-17    
Medline Journal Info:
Nlm Unique ID:  101291249     Medline TA:  Reprod Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-9     Citation Subset:  IM    
University of Vermont, Department of Neurology, Burlington, VT 05405, USA.
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MeSH Terms
Analysis of Variance
Angiography / methods
Calcitonin Gene-Related Peptide / metabolism,  pharmacology
Dose-Response Relationship, Drug
Microscopy, Video
Nerve Fibers / metabolism*
Norepinephrine / pharmacology
Posterior Cerebral Artery / drug effects,  innervation*,  physiology,  radiography
Postpartum Period / physiology*
Pregnancy, Animal / physiology*
Rats, Sprague-Dawley
Sex Factors
Trigeminal Nerve / anatomy & histology*,  growth & development,  metabolism
Tyrosine 3-Monooxygenase / metabolism
Ubiquitin Thiolesterase / metabolism
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Vasomotor System / anatomy & histology*,  growth & development,  metabolism
Grant Support
Reg. No./Substance:
0/Vasoconstrictor Agents; 0/Vasodilator Agents; 51-41-2/Norepinephrine; 83652-28-2/Calcitonin Gene-Related Peptide; EC 3-Monooxygenase; EC 3.1.2.-/PGP9.5 protein, rat; EC Thiolesterase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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