Document Detail

The influence of postnatal respiratory adaptation on sodium handling in preterm neonates.
MedLine Citation:
PMID:  2311548     Owner:  NLM     Status:  MEDLINE    
The relationship between sodium handling and alveolar-arterial oxygen gradient (AaDO2) was studied in 26 preterm babies requiring ventilation from birth. The difference between sodium intake and urinary sodium excretion was determined in sequential, four hourly periods throughout the course of the respiratory illness. Sodium retention changed from positive (mean 1.42 mmol kg-1 day-1) during the phase of deteriorating respiratory function to negative (mean - 1.99 mmol kg-1 day-1) during improving respiratory function. This difference is highly significant (P less than 0.001). A temporal relationship is also shown, in the form of individual time plots of AaDO2 and sodium retention for each baby; changes in sodium handling parallel changes in AaDO2. The diuresis that accompanies improving respiratory function is characterised as a natriuresis, with free water clearance remaining unchanged before and after the point of improvement. We suggest that a primary change in sodium handling, triggered by postnatal respiratory adaptation, may initiate the contraction in extracellular fluid volume that characterises early postnatal existence.
N Modi; J L Hutton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Early human development     Volume:  21     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  11-20     Citation Subset:  IM    
Department of Paediatrics, University of Liverpool, U.K.
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MeSH Terms
Adaptation, Physiological
Infant, Newborn
Infant, Premature / metabolism*
Kidney Function Tests
Respiratory Distress Syndrome, Newborn / metabolism*
Respiratory Function Tests
Sodium / metabolism*
Reg. No./Substance:

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