| The influence of phenobarbital on cytochromes and reactive oxygen species in erythropoietin producing HepG2 cells. | |
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MedLine Citation:
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PMID: 9872399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Light absorption photometry of HepG2 cells treated with phenobarbital for enhancing the content of cytochrome P-450 and the synthesis of erythropoietin revealed an influence on all cytochromes detectable in the wavelength range between 400 and 620 nm. No correlation was found between specific changes of cytochrome P-450 absorption and increased EPO synthesis as proposed earlier by Fandrey et al. (Life Sci. (1990) 47, 127-134). In the present study, however, the increased erythropoietin synthesis could be related to a decreased intracellular hydroxyl radical level described as crucial for the oxygen regulated gene expression (Kietzmann et al., Biochem. J. (1998) 335, 425-432; Porwol et al., Eur. J. Biochem. (1998) 256, 16-23). |
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Authors:
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W Ehleben; T Porwol; J Fandrey; H Acker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 440 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-01-25 Completed Date: 1999-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 343-7 Citation Subset: IM |
Affiliation:
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Max Planck Institut für molekulare Physiologie, Dortmund, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytochrome P-450 Enzyme System
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metabolism Cytochromes / drug effects*, metabolism Erythropoietin / biosynthesis*, genetics, metabolism Gene Expression Humans Hydroxyl Radical / metabolism Phenobarbital / pharmacology* Reactive Oxygen Species / metabolism* Spectrum Analysis Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Cytochromes; 0/Reactive Oxygen Species; 11096-26-7/Erythropoietin; 3352-57-6/Hydroxyl Radical; 50-06-6/Phenobarbital; 9035-51-2/Cytochrome P-450 Enzyme System |
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