Document Detail

The influence of phenobarbital on cytochromes and reactive oxygen species in erythropoietin producing HepG2 cells.
MedLine Citation:
PMID:  9872399     Owner:  NLM     Status:  MEDLINE    
Light absorption photometry of HepG2 cells treated with phenobarbital for enhancing the content of cytochrome P-450 and the synthesis of erythropoietin revealed an influence on all cytochromes detectable in the wavelength range between 400 and 620 nm. No correlation was found between specific changes of cytochrome P-450 absorption and increased EPO synthesis as proposed earlier by Fandrey et al. (Life Sci. (1990) 47, 127-134). In the present study, however, the increased erythropoietin synthesis could be related to a decreased intracellular hydroxyl radical level described as crucial for the oxygen regulated gene expression (Kietzmann et al., Biochem. J. (1998) 335, 425-432; Porwol et al., Eur. J. Biochem. (1998) 256, 16-23).
W Ehleben; T Porwol; J Fandrey; H Acker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  440     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-01-25     Completed Date:  1999-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  IM    
Max Planck Institut für molekulare Physiologie, Dortmund, Germany.
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MeSH Terms
Cytochrome P-450 Enzyme System / metabolism
Cytochromes / drug effects*,  metabolism
Erythropoietin / biosynthesis*,  genetics,  metabolism
Gene Expression
Hydroxyl Radical / metabolism
Phenobarbital / pharmacology*
Reactive Oxygen Species / metabolism*
Spectrum Analysis
Tumor Cells, Cultured
Reg. No./Substance:
0/Cytochromes; 0/Reactive Oxygen Species; 11096-26-7/Erythropoietin; 3352-57-6/Hydroxyl Radical; 50-06-6/Phenobarbital; 9035-51-2/Cytochrome P-450 Enzyme System

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