| The influence of particle size on the bioavailability of inhaled temazepam. | |
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MedLine Citation:
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PMID: 1389938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Temazepam was administered by aerosol using a standard protocol to healthy volunteers. Two studies are reported in which different dosage formulations were used: a) 30 mg of the 5 mu diameter particle (n = 6); b) 10 mg of the 2 mu diameter particle (n = 6). 2. An open crossover design was followed in each study. On one occasion in both studies subjects used a gargling procedure to remove drug which had been deposited in the mouth and oropharynx. 3. Serial venous blood samples were drawn for a period of 24 h. The mean total AUC of the 5 mu preparation was significantly reduced by gargling (3153 ng ml-1 h to 1066 ng ml-1 h) (F = 0.32). Gargling also had a significant effect on the mean AUC(0-1 h). 4. In contrast gargling had no significant effect on the mean AUC associated with the smaller diameter particle preparation (630 ng ml-1 h) vs 397 ng ml-1 h (F = 0.74). 5. These findings also indicate that temazepam deposition in the pulmonary tree is enhanced by the use of a 2 mu rather than a 5 mu diameter particle. However, the plasma drug concentrations achieved are unlikely to produce a sufficiently marked sedative effect for endoscopic investigations such as gastroscopy. |
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Authors:
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J P Fee; P S Collier; A P Launchbury; R S Clarke |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 33 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-11-19 Completed Date: 1992-11-19 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 641-4 Citation Subset: IM |
Affiliation:
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Department of Anaesthetics, Queen's University of Belfast, Northern Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Biological Availability Humans Male Particle Size Reference Values Temazepam / administration & dosage, blood, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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846-50-4/Temazepam |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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