| The influence of parity and gravidity on first trimester markers of chromosomal abnormality. | |
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MedLine Citation:
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PMID: 11038455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have studied changes in first trimester fetal nuchal translucency (NT) and maternal serum free beta-hCG and PAPP-A with gravidity and parity in 3252 singleton pregnancies unaffected by chromosomal abnormality or major pregnancy complications. We have shown that gravidity and parity is associated with a small but progressive decrease in fetal NT and a small but progressive increase in free beta-hCG and PAPP-A. None of these small changes with increasing gravidity or parity are statistically significant and hence correction for these variables is not necessary when considering first trimester screening for chromosomal abnormalities. |
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Authors:
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K Spencer; C Y Ong; A W Liao; K H Nicolaides |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 20 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-11-08 Completed Date: 2000-12-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 792-4 Citation Subset: IM |
Copyright Information:
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Copyright 2000 John Wiley & Sons, Ltd. |
Affiliation:
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Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK. Kevin_Spencer@Compuserve.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Chorionic Gonadotropin, beta Subunit, Human / blood* Down Syndrome / diagnosis* Female Gravidity* Humans Mass Screening / methods, standards Maternal Age Parity* Pregnancy Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A / metabolism* Prenatal Diagnosis* Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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