Document Detail


The influence of parity and gravidity on first trimester markers of chromosomal abnormality.
MedLine Citation:
PMID:  11038455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied changes in first trimester fetal nuchal translucency (NT) and maternal serum free beta-hCG and PAPP-A with gravidity and parity in 3252 singleton pregnancies unaffected by chromosomal abnormality or major pregnancy complications. We have shown that gravidity and parity is associated with a small but progressive decrease in fetal NT and a small but progressive increase in free beta-hCG and PAPP-A. None of these small changes with increasing gravidity or parity are statistically significant and hence correction for these variables is not necessary when considering first trimester screening for chromosomal abnormalities.
Authors:
K Spencer; C Y Ong; A W Liao; K H Nicolaides
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  20     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-08     Completed Date:  2000-12-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  792-4     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Ltd.
Affiliation:
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK. Kevin_Spencer@Compuserve.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Chorionic Gonadotropin, beta Subunit, Human / blood*
Down Syndrome / diagnosis*
Female
Gravidity*
Humans
Mass Screening / methods,  standards
Maternal Age
Parity*
Pregnancy
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / metabolism*
Prenatal Diagnosis*
Ultrasonography, Prenatal
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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