Document Detail


The influence of parental effects on transcriptomic landscape during early development in brook charr (Salvelinus fontinalis, Mitchill).
MedLine Citation:
PMID:  23299101     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parental effects represent an important source of variation in offspring phenotypes. Depending on the specific mechanisms involved, parental effects may be caused to different degrees by either the maternal or the paternal parent, and these effects may in turn act at different stages of development. To detect parental effects acting on gene transcription regulation and length phenotype during ontogeny, the transcriptomic profiles of two reciprocal hybrids from Laval × Rupert and Laval × Domestic populations of brook charr were compared at hatching, yolk sac resorption and 15 weeks after exogenous feeding. Using a salmonid cDNA microarray, our results show that parental effects modulated gene expression among reciprocal hybrids only at the yolk sac resorption stage. In addition, Laval × Domestic and Laval × Rupert reciprocal hybrids differed in the magnitude of theses parental effects, with 199 and 630 differentially expressed transcripts, respectively. This corresponds to a maximum of 18.5% of the analyzed transcripts. These transcripts are functionally related to cell cycle, nucleic acid metabolism and intracellular protein traffic, which is consistent with observed differences associated with embryonic development and growth differences in other fish species. Our results thus illustrate how parental effects on patterns of gene transcription seem dependent on the genetic architecture of the parents. In addition, in absence of transcriptional differences, non-transcript deposits in the yolk sac could contribute to the observed length differences among the reciprocal hybrids before yolk sac resorption.
Authors:
B Bougas; C Audet; L Bernatchez
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-09
Journal Detail:
Title:  Heredity     Volume:  110     ISSN:  1365-2540     ISO Abbreviation:  Heredity (Edinb)     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-17     Completed Date:  2014-01-06     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  0373007     Medline TA:  Heredity (Edinb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  484-91     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GEO/GSE42435
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Size / genetics
Chimera
Embryo, Nonmammalian
Embryonic Development / genetics*
Female
Gene Expression Profiling
Gene Expression Regulation, Developmental*
Male
Oligonucleotide Array Sequence Analysis
Phenotype
Trout / embryology*,  genetics
Yolk Sac / physiology
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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