| On the influence of oxygen and cell concentration in an SFPR whole cell biocatalytic Baeyer-Villiger oxidation process. | |
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MedLine Citation:
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PMID: 16444739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Efficient whole cell biotransformations, in particular microbial whole cell Baeyer-Villiger oxidation with molecular oxygen, demand comprehension and optimization of the process details involved. Optimal provision of oxygen and control of bioprocess parameters are pivotal for their success. The interrelation of cell density and oxygen supply in an in situ substrate feeding and product removal (SFPR) whole cell Baeyer-Villiger oxidation process was investigated in detail. Both parameters were optimized with respect to practical considerations. The outcome of this study supports a schematic process model, allows estimation of optimum process conditions and exploration of its limits. |
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Authors:
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Iris Hilker; Chris Baldwin; Véronique Alphand; Roland Furstoss; John Woodley; Roland Wohlgemuth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biotechnology and bioengineering Volume: 93 ISSN: 0006-3592 ISO Abbreviation: Biotechnol. Bioeng. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-23 Completed Date: 2006-05-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7502021 Medline TA: Biotechnol Bioeng Country: United States |
Other Details:
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Languages: eng Pagination: 1138-44 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Fluka Group, Industriestrasse 25, CH-9470 Buchs, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bicyclo Compounds, Heterocyclic
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metabolism Bioreactors / microbiology* Biotransformation Cell Division Escherichia coli / cytology, genetics, metabolism* Fermentation Ketones / metabolism* Kinetics Lactones / metabolism* Oxidation-Reduction Oxygen / analysis, metabolism* Oxygenases / genetics, metabolism* Partial Pressure |
| Chemical | |
Reg. No./Substance:
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0/Bicyclo Compounds, Heterocyclic; 0/Ketones; 0/Lactones; 7782-44-7/Oxygen; EC 1.13.-/Oxygenases; EC 1.14.13.-/cyclohexanone oxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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