| The influence of orifice height on flow rate of powder excipients. | |
| | |
MedLine Citation:
|
PMID: 22312701 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The influence of the orifice height of a cylindrical, flat-bottomed hopper on the mass flow rate of the free-flowable size fractions of sodium chloride and boric acid was investigated. It was observed that a zone of sudden acceleration of the mass flow under gravity occurred when a critical orifice height had been achieved. Based on the results, an orifice diameter equal to 12 mm with a height of between 8-16 mm is recommended for the faster flow of sodium chloride while an orifice diameter equal to 8 mm with a height of less than 8mm is appropriate for the slower flow of boric acid. In summary, the orifice height should be taken into consideration as an important parameter of a cylindrical test hopper in order to obtain a reproducible and comparable mass flow as the single-point characteristic of powder flowability. |
| | |
Authors:
|
Z Zatloukal; Z Sklubalová |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Die Pharmazie Volume: 66 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
|
Languages: eng Pagination: 953-5 Citation Subset: IM |
Affiliation:
|
Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Investigation of a new injectable thermosensitive hydrogel loading solid lipid nanoparticles.
Next Document: Formulation of PEG-ylated L-asparaginase loaded poly (lactide-co-glycolide) nanoparticles: influence...