Document Detail


The influence of new 9-(omega-[4-(2-pyrimidinyl)-1-piperazinyl]alkyl) pyrimidino[2,1-f]purines on the central nervous system.
MedLine Citation:
PMID:  8688890     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Synthesis and the results of preliminary pharmacological evaluation of four new 9-substituted pyrimidino[2,1-f]purines, containing pyrimidinyl-piperazine substituent are described. Some of these substances induced hypothermia, antagonism of amphetamine action and neurotoxic effects. All compounds had weaker activity on the central nervous system than previously studied compounds containing phenyl-piperazine substituent.
Authors:
D Malec; J Modzelewski; A Drabczyńska; M Pawłowski; M Gorczyca
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Polish journal of pharmacology     Volume:  47     ISSN:  1230-6002     ISO Abbreviation:  Pol J Pharmacol     Publication Date:    1995 Mar-Apr
Date Detail:
Created Date:  1996-08-29     Completed Date:  1996-08-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9313882     Medline TA:  Pol J Pharmacol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
Affiliation:
Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects*
Male
Mice
Psychotropic Drugs / adverse effects,  chemistry,  pharmacology*
Purines / adverse effects,  chemistry,  pharmacology*
Rats
Rats, Wistar
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Psychotropic Drugs; 0/Purines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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