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The influence of neural cell adhesion molecule isoform 140 on the metastasis of thyroid carcinoma.
MedLine Citation:
PMID:  23015367     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We previously showed that the preservation of neural adhesion molecule (NCAM) in differentiated thyroid carcinoma is an important indicator for a higher risk of distant metastasis. In the present study, we further demonstrated that forced NCAM-140 isoform expression in human thyroid cancer cells could lead to aggressive growth by enhancing migration and anchorage-independent growth, and exhibiting partial features of epithelial mesenchymal transition. More extensive distant metastasis was also noted in an animal xenograft model when NCAM-expressing thyroid cancer cells were introduced into mice intravascularly. Bioinformatic analysis of NCAM-associated expression profiles predicted a highly interactive protein network, which further implies potential molecular mechanisms underlying the metastatic processes of thyroid cancer.
Authors:
An-Hang Yang; Yat-Pang Chau; Chen-Hsen Lee; Jui-Yu Chen; Jun-Yi Chen; Chien-Chih Ke; Ren-Shyan Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Clinical & experimental metastasis     Volume:  -     ISSN:  1573-7276     ISO Abbreviation:  Clin. Exp. Metastasis     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8409970     Medline TA:  Clin Exp Metastasis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pathology, Taipei Veterans General Hospital, Rm. 6047, Medical Technology Building, Taipei, 11217, Taiwan, ahyang@vghtpe.gov.tw.
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