| The influence of network structure on the transport of blood in the human cerebral microvasculature. | |
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MedLine Citation:
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PMID: 22111581 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this paper we explore how the structural properties of miniature networks influence the transport of blood through the human cerebral microvasculature. We propose four methods for generating such networks and investigate both how the resulting network properties match available experimental data from the human cortex and how these properties affect the flow of blood through the networks. Since the nature of such microvascular flow patterns is inherently random, we run multiple simulations. We find that the modified spanning tree method (MSTM) produces artificial networks having characteristics closest to those of the microvasculature in human brain and also allows for high network flow passage per unit material cost, being statistically significantly better than three other methods considered here. Such results are potentially extremely valuable in interpreting experimental data acquired from humans and in improving our understanding of cerebral blood flow at this very small length scale. This could have significant impact on improving clinical outcomes for vascular brain diseases, particularly vascular dementia, where localized flow patterns are very important. |
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Authors:
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Shen-Wei Su; Mark Catherall; Stephen Payne |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-23 |
Journal Detail:
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Title: Microcirculation (New York, N.Y. : 1994) Volume: - ISSN: 1549-8719 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434935 Medline TA: Microcirculation Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons Ltd. |
Affiliation:
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Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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