Document Detail


The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas.
MedLine Citation:
PMID:  22129386     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
In addition to a nutritive role, human milk also guides the development of a protective intestinal microbiota in the infant. Human milk possesses an overabundance of complex oligosaccharides that are indigestible by the infant yet are consumed by microbial populations in the developing intestine. These oligosaccharides are believed to facilitate enrichment of a healthy infant gastrointestinal microbiota, often associated with bifidobacteria. Advances in glycomics have enabled precise determination of milk glycan structures as well as identification of the specific glycans consumed by various gut microbes. Furthermore, genomic analysis of bifidobacteria from infants has revealed specific genetic loci related to milk oligosaccharide import and processing, suggesting coevolution between the human host, milk glycans, and the microbes they enrich. This review discusses the current understanding of how human milk oligosaccharides interact with the infant microbiota and examines the opportunities for translating this knowledge to improve the functionality of infant formulas.
Authors:
Maciej Chichlowski; J Bruce German; Carlito B Lebrilla; David A Mills
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annual review of food science and technology     Volume:  2     ISSN:  1941-1413     ISO Abbreviation:  Annu Rev Food Sci Technol     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101561951     Medline TA:  Annu Rev Food Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  331-51     Citation Subset:  IM    
Affiliation:
Foods for Health Institute, University of California, Davis, California 95616;
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