| The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipients. | |
| | |
MedLine Citation:
|
PMID: 16005194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this work the Hammett acidity function has been measured to assess the relative acidity of excipients used in the preparation of pharmaceutical solid dosage forms. A systematic series of experiments is reported which illustrates how the selection of the measurement conditions can influence the results of such determinations. Although the technique is somewhat empirical and relies on several key assumptions it is shown that very consistent results can be achieved by carefully controlling the measurement conditions. It is also shown that by taking this approach laboratory-to-laboratory variation can be reduced to a negligible level and the influences of subtle changes in the acidity of pharmaceutical excipients due to intrinsic variations in their physical properties or due to different processing histories can be detected and quantified. |
| | |
Authors:
|
Andrey V Zinchuk; Bruno C Hancock; Evgenyi Y Shalaev; Renuka D Reddy; Ramprakash Govindarajan; Elizabeth Novak |
Related Documents
:
|
16970054 - Increased plasma homocysteine and allantoin levels in coronary artery disease: possible... 14691614 - Carbamazepine markedly reduces serum concentrations of simvastatin and simvastatin acid. 11924864 - On the relationship between acid rain and cloud type. 645914 - Quantitation of renal uric acid synthesis in the chicken. 9819004 - Absorption and elimination of alpha-thrombin and tranexamic acid after fibrin sealant a... 4580574 - Amino acid transport in a polyaromatic amino acid auxotroph of saccharomyces cerevisiae. |
Publication Detail:
|
Type: Journal Article Date: 2005-07-06 |
Journal Detail:
|
Title: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V Volume: 61 ISSN: 0939-6411 ISO Abbreviation: Eur J Pharm Biopharm Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-10-11 Completed Date: 2005-12-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9109778 Medline TA: Eur J Pharm Biopharm Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 158-70 Citation Subset: IM |
Affiliation:
|
Pfizer Inc., Groton, CT 06340, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Calibration Chemistry, Pharmaceutical Excipients / chemistry* Hydrogen-Ion Concentration Lubrication |
| Chemical | |
Reg. No./Substance:
|
0/Excipients |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An experimental investigation of the stability of ethylcellulose latex: correlation between zeta pot...
Next Document: Enhanced efficacy of triprolidine by transdermal application of the EVA matrix system in rabbits and...