Document Detail


The influence of measurement conditions on the Hammett acidity function of solid pharmaceutical excipients.
MedLine Citation:
PMID:  16005194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this work the Hammett acidity function has been measured to assess the relative acidity of excipients used in the preparation of pharmaceutical solid dosage forms. A systematic series of experiments is reported which illustrates how the selection of the measurement conditions can influence the results of such determinations. Although the technique is somewhat empirical and relies on several key assumptions it is shown that very consistent results can be achieved by carefully controlling the measurement conditions. It is also shown that by taking this approach laboratory-to-laboratory variation can be reduced to a negligible level and the influences of subtle changes in the acidity of pharmaceutical excipients due to intrinsic variations in their physical properties or due to different processing histories can be detected and quantified.
Authors:
Andrey V Zinchuk; Bruno C Hancock; Evgenyi Y Shalaev; Renuka D Reddy; Ramprakash Govindarajan; Elizabeth Novak
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Publication Detail:
Type:  Journal Article     Date:  2005-07-06
Journal Detail:
Title:  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V     Volume:  61     ISSN:  0939-6411     ISO Abbreviation:  Eur J Pharm Biopharm     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-11     Completed Date:  2005-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109778     Medline TA:  Eur J Pharm Biopharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  158-70     Citation Subset:  IM    
Affiliation:
Pfizer Inc., Groton, CT 06340, USA.
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MeSH Terms
Descriptor/Qualifier:
Calibration
Chemistry, Pharmaceutical
Excipients / chemistry*
Hydrogen-Ion Concentration
Lubrication
Chemical
Reg. No./Substance:
0/Excipients

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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