Document Detail

The influence of the maternal uterine immune response on placentation in human subjects.
MedLine Citation:
PMID:  10343342     Owner:  NLM     Status:  MEDLINE    
The immunological relationship between the mammalian fetus and its mother during pregnancy has been considered similar to that between a transplanted allograft and its recipient ever since Medawar (1953) first proposed the concept of the 'fetus as an allograft' in the early 1950s. Based on this analogy, it has been assumed that implantation of the fetal placenta in the uterus would be controlled similarly by a maternal immune response mediated by T-cells recognizing paternally-derived alloantigens expressed by the placenta. Surprisingly, recent evidence suggests that implantation might involve predominantly a novel allogeneic recognition system based on natural killer cells rather than T-cells (Loke & King, 1995). The cellular and molecular basis of this local immune interaction between the fetal placenta and maternal uterus is now the focus of intense research interest. Since aberrant implantation can cause a variety of clinical problems, including miscarriage, intrauterine growth retardation and pre-eclampsia, an understanding of the immunological mechanism by which this process is controlled could lead to the development of regimens to improve fetal growth and development.
A King; Y W Loke
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Proceedings of the Nutrition Society     Volume:  58     ISSN:  0029-6651     ISO Abbreviation:  Proc Nutr Soc     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-07-09     Completed Date:  1999-07-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7505881     Medline TA:  Proc Nutr Soc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  IM    
Department of Pathology, University of Cambridge, UK.
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MeSH Terms
Embryonic and Fetal Development
HLA Antigens / analysis
Killer Cells, Natural / immunology
Leukocytes / immunology
Trophoblasts / immunology
Uterus / immunology*
Reg. No./Substance:
0/HLA Antigens

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