| The influence of maternal opiate use in pregnancy on second trimester biochemical markers for Down syndrome. | |
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MedLine Citation:
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PMID: 19488976 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: The object of this study is to examine the influence of maternal opiate use on the levels of second trimester biochemical markers for Down syndrome. Maternal opiate use is known to be associated with problems of placental origin and it is possible that the secretion of alpha-feto protein (AFP), free-beta human chorionic gonadotrophin (HCG) and unconjugated oestriol (UE) differs from that of a normal population. METHOD: Seventy nine women who used opiates in pregnancy were compared to a control group of seventy nine women who did not use opiates and their adjusted marker levels analysed. RESULTS: The adjusted median MoM in the opiate and control groups respectively were: AFP (1.00 vs 0.94), HCG (0.95 vs 1.04) and UE (0.96 vs 1.02), with no significant difference between these groups. CONCLUSION: This study suggests that the current practice of calculating the risk of Down syndrome from second trimester biochemistry in women using opiate can be performed using data derived from a normal population. |
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Authors:
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G J Scott; S Holding; A Purcell; S Tutty; S W Lindow |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 29 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 863-5 Citation Subset: IM |
Affiliation:
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Women and Children's Hospital, Hull Royal Infirmary, Hull, East Yorkshire, HU3 2JZ, England. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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