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The influence of maternal cortisol and emotional state during pregnancy on fetal intrauterine growth.
MedLine Citation:
PMID:  22669293     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:This exploratory study investigates the influence of maternal cortisol and emotional state during pregnancy on fetal intra-uterine growth (IUG). We expected higher basal cortisol levels, or more depressive and anxious complaints during pregnancy, to be associated with slower IUG and lower birth weight.Methods:91 pregnant women were recruited from the antenatal clinic and were seen once each trimester. Next to psychological assessments, a diurnal cortisol profile was derived from saliva samples. IUG was evaluated using ultrasound.Results:In mid-pregnancy (T2) basal cortisol levels significantly predicted the variance of weight (Proportion of variance in growth variable explained (PVE)=11.6%) and body mass index (BMI) at birth (PVE=6.8%). In late-pregnancy (T3) emotional state, particularly depressive symptoms (BMI at Birth: PVE=6.9%; Ponderal Index (PI) at birth: PVE=8.2%; head circumference at T3: PVE=10.3%; head circumference at birth PVE=9.1%) and attachment (BMI at Birth: PVE=6.9%; PI at birth: PVE=7.2%) had an influence on growth.Analysis of growth between T2 and T3 showed that attachment and cortisol in T3 had an influence on the variation in increase in estimated fetal weight (PVE=12.5% - PVE=8.6%).Conclusion:These data indicate basal cortisol levels were more important in T2. Whereas emotional state was more important in T3.
Authors:
Titia Hompes; Elske Vrieze; Steffen Fieuws; Annelies Simons; Liesbeth Jaspers; Johan Van Bussel; Ganel Schops; Edith Gellens; Rieta Van Bree; Johan Verhaeghe; Bernard Spitz; Koen Demyttenaere; Karel Allegaert; Bea Van den Bergh; Stephan Claes
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-05
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Psychiatry, University Hospitals Leuven, 3000 Leuven, Belgium.
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