Document Detail

The influence of maternal body mass index on infant adiposity and hepatic lipid content.
MedLine Citation:
PMID:  21629154     Owner:  NLM     Status:  MEDLINE    
Maternal overweight and obesity are associated with adverse offspring outcome in later life. The causal biological effectors are uncertain. Postulating that initiating events may be alterations to infant body composition established in utero, we tested the hypothesis that neonatal adipose tissue (AT) content and distribution and liver lipid are influenced by maternal BMI. We studied 105 healthy mother-neonate pairs. We assessed infant AT compartments by whole body MR imaging and intrahepatocellular lipid content by H MR spectroscopy. Maternal BMI ranged from 16.7 to 36.0. With each unit increase in maternal BMI, having adjusted for infant sex and weight, there was an increase in infant total (8 mL; 95% CI, 0.09-14.0; p = 0.03), abdominal (2 mL; 95% CI, 0.7-4.0; p = 0.005), and nonabdominal (5 mL; 95% CI, 0.09-11.0; p = 0.054) AT, and having adjusted for infant sex and postnatal age, an increase of 8.6% (95% CI, 1.1-16.8; p = 0.03) in intrahepatocellular lipid. Infant abdominal AT and liver lipid increase with increasing maternal BMI across the normal range. These effects may be the initiating determinants of a life-long trajectory leading to adverse metabolic health.
Neena Modi; Dominika Murgasova; Rikke Ruager-Martin; E Louise Thomas; Matthew J Hyde; Christopher Gale; Shalini Santhakumaran; Caroline J Doré; Afshin Alavi; Jimmy D Bell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  70     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-08     Completed Date:  2011-12-06     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-91     Citation Subset:  IM    
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MeSH Terms
Abdominal Fat
Body Composition
Body Mass Index*
Body Weight
Child, Preschool
Great Britain
Infant, Newborn*
Lipids / analysis*
Liver / chemistry*
Obesity / complications
Overweight / complications
Prenatal Exposure Delayed Effects*
Grant Support
MC_U120061305//Medical Research Council; //Medical Research Council
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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