Document Detail


The influence of magnesium ions on pyruvate kinase-deficient red blood cells.
MedLine Citation:
PMID:  54308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of intravenous and oral administration of magnesium containing drug (Magnesium Diasporal, Protina, München) on the erythrocyte pyruvate kinase (PK) activity in two cases of congenital nonspherocytic hemolytic anemia associated with PK deficiency has been examined. Intravenous injection of the drug has been followed by transient increase in magnesium content. Positive correlation between erythrocyte magnesium ions concentration and PK activity has been found. The authors propose a hypothesis that the observed correlation may be due to the erythrocyte accumulation of some PK activators or to the elimination of some PK inhibitors. The authors did not, however, succeed to maintain the high erythrocyte magnesium concentration inducing the increase in PK activity during the longer period of time.
Authors:
M Wazewska-Czyzewska; M Gumińska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia haematologica (Leipzig, Germany : 1928)     Volume:  102     ISSN:  0323-4347     ISO Abbreviation:  Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch.     Publication Date:  1975  
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374615     Medline TA:  Folia Haematol Int Mag Klin Morphol Blutforsch     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  576-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Anemia, Hemolytic, Congenital Nonspherocytic / metabolism
Erythrocytes / drug effects,  enzymology*
Female
Humans
Injections, Intravenous
Magnesium / administration & dosage,  blood,  pharmacology*
Pyruvate Kinase / deficiency*
Chemical
Reg. No./Substance:
7439-95-4/Magnesium; EC 2.7.1.40/Pyruvate Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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