Document Detail

The influence of lung function on exercise capacity in patients with type 2 diabetes.
MedLine Citation:
PMID:  20518255     Owner:  NLM     Status:  MEDLINE    
Patients with type 2 diabetes have impaired exercise capacity. While numerous factors are known to contribute to impaired exercise capacity, the role of lung function remains unclear. We conducted the present study to investigate the influence of lung function on exercise capacity in patients with type 2 diabetes. Cardiopulmonary exercise testing was carried out in 31 male patients with type 2 diabetes without diabetic complications or cardiopulmonary diseases. Patients with abnormal spirometry results such as a percentage of predicted forced vital capacity (%FVC) < 80% and/or a ratio of forced expiratory volume in one second (FEV1) to FVC (FEV1/FVC) < 70% were excluded from the study. We used the percentage of predicted maximal oxygen uptake (%VO2max) as an index of exercise capacity. The correlations between %VO2max and lung function and other factors known to be associated with impaired exercise capacity were then assessed. Univariate analysis revealed %VO2max correlated significantly with percentage of predicted FEV1 (%FEV1), duration of type 2 diabetes, regular exercise habits, and systolic and diastolic blood pressures. In a multivariate analysis, %FEV1 and regular exercise habits were found to be independent determinants of %VO2max. A mild reduction in %FEV1, which may be a complication of diabetes, is associated with impaired exercise capacity in patients with type 2 diabetes. When evaluating spirometric values in patients with type 2 diabetes, a reduction in %FEV1 should be noted even when both %FVC and FEV1/FVC are within normal limits.
Yoshihiro Kitahara; Noboru Hattori; Akihito Yokoyama; Kiminori Yamane; Kiyokazu Sekikawa; Tsutomu Inamizu; Nobuoki Kohno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hiroshima journal of medical sciences     Volume:  59     ISSN:  0018-2052     ISO Abbreviation:  Hiroshima J. Med. Sci.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-06-03     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421060     Medline TA:  Hiroshima J Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  7-13     Citation Subset:  IM    
Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Graduate School of Biochemical Sciences, Hiroshima University, Hiroshima, Japan.
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MeSH Terms
Blood Pressure
Diabetes Mellitus, Type 2 / physiopathology*
Exercise Test
Exercise Tolerance*
Forced Expiratory Volume
Lung / physiopathology*
Middle Aged
Oxygen Consumption
Vital Capacity

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