| The influence of low oxygen on macrophage response to Leishmania infection. | |
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MedLine Citation:
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PMID: 21517930 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hypoxia (low oxygen tension) is a common feature of inflamed and infected tissues. The influence of hypoxia on macrophage responses to microorganisms has only recently been studied. This study demonstrates that hypoxia induced macrophages to control Leishmania amazonensis, an intracellular parasite which causes cutaneous and cutaneous metastatic lesions. The mechanisms which contribute to the control of macrophages against L. amazonensis infection under a hypoxic microenvironment are not known. Nitric oxide, TNF-α, IL-10 or IL-12 are not responsible for the decrease in parasitism under hypoxia. Live L. amazonensis entry or exocytoses of internalized particles as well as energetic metabolism were not impaired in infected macrophages; no apoptosis-like death was detected in intracellular parasites. Reactive oxygen species (ROS) is likely to be involved, since treatment with antioxidants N-acetylcysteine (NAC) and ebselen inhibit the leishmanicidal effect of macrophages under hypoxia. L. amazonensis infection induces macrophages to express hypoxia-inducible factor-1 (HIF-1α) and -2 (HIF-2α). Data indicate that hypoxia affects the microbial activities and protein expression of macrophages leading to a different phenotype from that of the normoxic counterpart, and that it plays a role in modulating Leishmania infection. |
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Authors:
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Adriana Degrossoli; Wagner Welber Arrais-Silva; Marcele Carolina Colhone; Fernanda Ramos Gadelha; Paulo Pinto Joazeiro; Selma Giorgio |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-23 |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: - ISSN: 1365-3083 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Animal Biology, Biology Institute, Universidade Estadual de Campinas, Caixa Postal 6109, 13083-970, Campinas, São Paulo, Brazil. Departament of Biochemistry, Biology Institute, Universidade Estadual de Campinas. Departament of Histology and Embriology, Biology Institute, Universidade Estadual de Campinas. |
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