Document Detail

The influence of liquid crystalline phases on drug percutaneous absorption. I. Development of a vehicle.
MedLine Citation:
PMID:  1488396     Owner:  NLM     Status:  MEDLINE    
A phase diagram approach has been used to formulate topically applied vehicles containing liquid crystalline phases. The current paper describes the construction of a major portion of the polyoxyethylene(20)cetyl ether:dodecanol:water phase diagram. Known mixtures of the three components were equilibrated and centrifuged to separate the resultant conjugate phases. These were identified and analyzed quantitatively to determine phase boundaries in relevant portions of the phase diagram. Two isotropic liquid phases, several two- and three-phase regions, a solid surfactant phase, and at least three distinct liquid crystalline phases were identified. The determination of tie lines was undertaken in a two-phase region containing an aqueous isotropic micellar solution and a liquid crystalline gel. This information will be used to prepare a number of vehicles of known phase composition and concentration for a systematic evaluation of the effect of liquid crystalline phases on transdermal drug delivery.
J Swarbrick; J R Siverly
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmaceutical research     Volume:  9     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-19     Completed Date:  1993-02-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1546-9     Citation Subset:  IM    
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
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MeSH Terms
Chemistry, Pharmaceutical
Chemistry, Physical
Physicochemical Phenomena
Skin Absorption*
Reg. No./Substance:
0/Emulsions; 0/Micelles; 0/Vehicles

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