Document Detail

The influence of liposome-encapsulated prostaglandin E1 on hydrogen peroxide concentrations in the exhaled breath of patients with the acute respiratory distress syndrome.
MedLine Citation:
PMID:  10439747     Owner:  NLM     Status:  MEDLINE    
IMPLICATIONS: White blood cells (WBC) are thought to be part of the cause of the acute respiratory distress syndrome, a lung disease. WBC in the lung produce hydrogen peroxide, which is exhaled. Liposomal PGE1 inhibits WBC function but was found to have no effect in decreasing exhaled hydrogen peroxide in patients with the acute respiratory distress syndrome.
S O Heard; K Longtine; I Toth; J C Puyana; B Potenza; N Smyrnios
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  89     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-08-24     Completed Date:  1999-08-24     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  353-7     Citation Subset:  AIM; IM    
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MeSH Terms
Alprostadil / administration & dosage*
Breath Tests*
Drug Carriers
Hydrogen Peroxide / analysis*
Infusions, Intravenous
Leukocyte Count
Middle Aged
Respiratory Distress Syndrome, Adult / blood,  metabolism*,  therapy
Reg. No./Substance:
0/Drug Carriers; 0/Liposomes; BBX060AN9V/Hydrogen Peroxide; F5TD010360/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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