| The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats. | |
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MedLine Citation:
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PMID: 12841641 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adriamycin widely used in the treatment of neoplastic conditions is nephrotoxic. In the present study the protective effect of lipoic acid was investigated in adriamycin-induced nephrotoxicity in adult male albino Wistar rats. Adriamycin-induced nephrotoxicity was characterized by hyperlipidemia, proteinuria, and hypoproteinemia, by decreased activities of the enzymes N-acetyl-beta-D-glucosaminidase and cathepsin D, by increased lipid peroxidation and decreases in serum catalase and glutathione activities, and by increased urinary and serum urea, creatinine and urinary glycosaminoglycans. Pretreatment with lipoic acid restored the changes, indicating that lipoic acid is renoprotective in adriamycin nephrotoxicity. |
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Authors:
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Kumaravel Palanichamy Malarkodi; Andithangal Venkatesan Balachandar; Palaninathan Varlakshmi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 247 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-07-04 Completed Date: 2004-04-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 139-45 Citation Subset: IM |
Affiliation:
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Department of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylglucosaminidase
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drug effects,
metabolism Animals Antioxidants / metabolism Catalase / blood, drug effects Cathepsin D / drug effects, metabolism Cholesterol / metabolism Creatinine / urine Doxorubicin / adverse effects* Glutathione / blood Glycosaminoglycans / metabolism Hyperlipidemias / chemically induced*, complications, metabolism Kidney / drug effects*, metabolism, pathology Kidney Diseases / chemically induced, etiology Lipid Peroxidation / drug effects Male Protective Agents / pharmacology Proteinuria / chemically induced Rats Rats, Wistar Thioctic Acid / pharmacology* Triglycerides / metabolism Urea / blood |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Glycosaminoglycans; 0/Protective Agents; 0/Triglycerides; 23214-92-8/Doxorubicin; 57-13-6/Urea; 57-88-5/Cholesterol; 60-27-5/Creatinine; 62-46-4/Thioctic Acid; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 3.2.1.52/Acetylglucosaminidase; EC 3.4.23.5/Cathepsin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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