Document Detail


The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.
MedLine Citation:
PMID:  12841641     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adriamycin widely used in the treatment of neoplastic conditions is nephrotoxic. In the present study the protective effect of lipoic acid was investigated in adriamycin-induced nephrotoxicity in adult male albino Wistar rats. Adriamycin-induced nephrotoxicity was characterized by hyperlipidemia, proteinuria, and hypoproteinemia, by decreased activities of the enzymes N-acetyl-beta-D-glucosaminidase and cathepsin D, by increased lipid peroxidation and decreases in serum catalase and glutathione activities, and by increased urinary and serum urea, creatinine and urinary glycosaminoglycans. Pretreatment with lipoic acid restored the changes, indicating that lipoic acid is renoprotective in adriamycin nephrotoxicity.
Authors:
Kumaravel Palanichamy Malarkodi; Andithangal Venkatesan Balachandar; Palaninathan Varlakshmi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  247     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-07-04     Completed Date:  2004-04-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Affiliation:
Department of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India.
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MeSH Terms
Descriptor/Qualifier:
Acetylglucosaminidase / drug effects,  metabolism
Animals
Antioxidants / metabolism
Catalase / blood,  drug effects
Cathepsin D / drug effects,  metabolism
Cholesterol / metabolism
Creatinine / urine
Doxorubicin / adverse effects*
Glutathione / blood
Glycosaminoglycans / metabolism
Hyperlipidemias / chemically induced*,  complications,  metabolism
Kidney / drug effects*,  metabolism,  pathology
Kidney Diseases / chemically induced,  etiology
Lipid Peroxidation / drug effects
Male
Protective Agents / pharmacology
Proteinuria / chemically induced
Rats
Rats, Wistar
Thioctic Acid / pharmacology*
Triglycerides / metabolism
Urea / blood
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Glycosaminoglycans; 0/Protective Agents; 0/Triglycerides; 23214-92-8/Doxorubicin; 57-13-6/Urea; 57-88-5/Cholesterol; 60-27-5/Creatinine; 62-46-4/Thioctic Acid; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 3.2.1.52/Acetylglucosaminidase; EC 3.4.23.5/Cathepsin D

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